Waters Library - Selected Documents




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Estabilishing a Ketoconazole Suppression Test for Verifying Testosterone Administration in the Doping Control of Athletes
Library Number   940739


Comparison of the structure property relationships in LB films of zwitterionic TCNQ adducts
Library Number   NP17277


Isobutene-isoprene copolymerization initiated by [Cp(*)MMe(2)][(n-C(18)H(37)E)B(C(6)F(5))(3)] (M = Ti, Hf: E = O, S) and related compounds
Library Number   NP18006


Synthetic peptide derived from α-fetoprotein inhibits growth of human breast cancer: investigation of the pharmacophore and synthesis optimization
Library Number   NP18099


On peptide de novo sequencing: a new approach
Library Number   NP18148


Geochemical characteristics of oil seepages from Dam Thi Nai, Central Vietnam: Implications for hydrocarbon exploration in the offshore Phu Khanh Basin
Library Number   NP18163


Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT(1A)) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2- ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: Relationship with 5-HT(1A) receptor occupancy and kinetic parameters
Library Number   NP18254


Dynamics of β-amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor
Library Number   NP18256


Comparison study between the mechanisms of allergic asthma amelioration by a cysteinyl-leukotriene type 1 receptor antagonist montelukast and methylprednisolone
Library Number   NP18259


Regulation of human Hepatocytes by P2Y receptors: Control of glycogen phosphorylase, Ca(2+) , and mitogen-activated protein kinases
Library Number   NP18264


Pharmacokinetics and distribution of sodium 3,4-diaminonaphthalene-1-sulfonate, a Congo Red derivative active in inhibiting PrP(res) replication
Library Number   NP18317


Concentration dependency of modulatory effect of amlodipine on P-glycoprotein efflux activity of doxorubicin - a comparison with tamoxifen
Library Number   NP18325


Phototransformation of 3,5-dihalogeno-4-hydroxybenzonitriles (ioxynil and chloroxynil) in aqueous solution
Library Number   NP18364


Novel poly(arylene)s with pendant trifluoromethyl groups by Ni(0) catalyzed coupling reaction
Library Number   NP18536


Effect of cocatalyst on the chain microstructure of polyethylene made with CGC-Ti/MAO/B(C(6)F(5))(3)
Library Number   NP18718


Synthesis and photoluminescence of linear and hyperbranched polyethers containing phenylquinoxaline units and flexible aliphatic spacers
Library Number   NP18778


Aliphatic-aromatic copolyesters derived from 2,2,4,4-tetramethyl-1,3-cyclobutanediol
Library Number   NP18780


Associative block copolymers comprising poly(N-isopropylacrylamide) and poly(ethylene oxide) end-functionalized with a fluorophilic or hydrophilic group. Synthesis and aqueous solution properties
Library Number   NP18789


Dithiocarbamate mediated controlled/living free radical polymerization of methyl acrylate under (60)Co γ-ray irradiation: Conjugation effect of N-group
Library Number   NP18795


Svnthesis and characterization of random and block copolymers with pendant rhenium diimine complexes by controlled radical polymerization
Library Number   NP18824


Synthesis and characterization of telechelic polymethacrylates via RAFT polymerization
Library Number   NP18825


Microstructure determination of methyl methacrylate and n-butyl acrylate copolymers synthesized by atom transfer radical polymerization with two-dimensional NMR spectroscopy
Library Number   NP18831


Diblock and triblock copolymers of styrene and acetoxymethylstyrene by one-pot ATRP
Library Number   NP18836


Ethylene polymerization with silica-supported bis[3,5-dinitro-N-(2,6-di isopropylphenyl) salicylaldiminatel]nickel (II)/methylaluminoxane catalysts
Library Number   NP18850


Functionalization of poly(ethylene terephthalate) in the melt state: Chemical and rheological aspects
Library Number   NP18856


Novel saturated red-emitting poly(p-phenylenevinylene) copolymers with narrow-band-gap units of 2,1,3-benzothiadiazole synthesized by a palladium-catalyzed Stille coupling reaction
Library Number   NP18858


Two-sided comb poly(amic graft copolymers as porous ester)-poly(propylene oxide) polyimide precursors
Library Number   NP18861


Metallocenic copolymers of ethylene and 5,7-dimethylocta-1,6-diene: Structural characterization and mechanical behavior
Library Number   NP18897


Phenyl biliverdin isomers obtained by chemical oxidation of iron(III) complex of 5-phenyl protoporphyrin IX
Library Number   NP18910


Site-specific lipophilic modification of interferon-alpha
Library Number   NP18917


Molecular mass distributions of lignin and lignin-carbohyd rate complexes in birch Kraft pulps: Changes caused by the conditions in the cook and their relation to unbleached pulp brightness and bleachability
Library Number   NP18937


Microbial kinetic controls on calcite morphology in supersaturated solutions
Library Number   NP18971


Structural elucidation of catechin and epicatechin in sorrel leaf extracts using liquid-chromatography coupled to diode array-, fluorescence-, and mass spectrometric detection
Library Number   NP19040


Semipreparative isolation of dehydrodiferulic and dehydrotriferulic acids as standard substances from maize bran
Library Number   NP19050


Development and characterisation of a molecularly imprinted polymer prepared by precipitation polymerisation for the determination of phenylurea herbicides
Library Number   NP19078


A validated gas chromatographic method for the evaluation of enzymatic enatioselectivity in kinetic resolution applications
Library Number   NP19083


Supercritical fluid chromatography tandem-column method development in pharmaceutical sciences for a mixture of four stereoisomers
Library Number   NP19086


Metabolism of dehydroepiandrosterone by rodent brain cell lines: Relationship between 7-hydroxylation and aromatization
Library Number   NP19111


Gene silencing pathway RNA-dependent RNA polymerase of Neurospora crassa: yeast expression and crystallization of selenomethionated QDE-1 protein
Library Number   NP19118


Supercritical fluids extraction of Ginkgo ginkgolides and flavonoids
Library Number   NP19121


Characterization of alcohol ethoxylates as alcohol ethoxy sulfate derivatives by liquid chromatography-mass spectrometry
Library Number   NP19132


Relative contribution of endogenous opioids to myocardial ischemic tolerance
Library Number   NP19142


A novel process for physically refining rice bran oil through simultaneous degumming and dewaxing
Library Number   NP19204


Rootstocks and plant water relations affect sugar accumulation of citrus fruit via osmotic adjustment
Library Number   NP19223


Monitoring of pesticides and polycyclic aromatic hydrocarbons in water from Paraiba do Sul River, Brazil
Library Number   NP19248


Triterpenoid saponins from stem bark of pentaclethra macroloba
Library Number   NP19252


New Hg2+-selective fluoroionophores derived from p-tert-butylcalix[4]arene-azacrown ethers
Library Number   NP19313


Total phenol, flavonoid, proanthocyanidin and vitamin C levels and antioxidant activities of Mauritian vegetables
Library Number   NP19480


Influence of wine turbidity on the accumulation of biogenic amines during aging
Library Number   NP19482


Investigations on the conversion of onion aroma precursors S-alk(en)yl-L-cysteine sulphoxides in onion juice production
Library Number   NP19487


Heat-induced denaturation impairs digestibility of legume (Phaseolus vulgaris L and Vicia faba L) 7S and 11S globulins in the small intestine of rat
Library Number   NP19494


Effect of high-pressure processing on the migration of antioxidant Irganox 1076 from polypropylene film into a food simulant
Library Number   NP19496


Nutritional value of African yambean (Sphenostylis stenocarpa L): improvement by lactic acid fermentation
Library Number   NP19504


Interaction of pharmaceutical hydrates with supercritical CO(2) - Solubility, solid-state and chemical modifications
Library Number   NP19528


Photostability of triprolidine hydrochloride and its mixtures with cyclodextrin and glucose
Library Number   NP19529


In vitro conjugation of ethanolamine with fatty acids by rat liver subcellular fractions
Library Number   NP19541


Transduction of peptide analogs of the small heat shock-related protein HSP20 inhibits intimal hyperplasia
Library Number   NP19556


Comparative metabolic excretion profile of sodium salicylate in broiler chickens and homing pigeons
Library Number   NP19581


Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected A549 cells identified by high-resolution two-dimensional gel electrophoresis
Library Number   NP19603


Identification of proteins associated with murine cytomegalovirus virions
Library Number   NP19604


Emergence of a drug-dependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor
Library Number   NP19606


Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN-gp120 interaction
Library Number   NP19610


Vasopeptidase inhibitor restores the balance of vasoactive hormones in progressive nephropathy
Library Number   NP19681


A physiological study on growth and dibenzothiophene (DBT) desulfurization characteristics of Gordonia sp. CYKS1
Library Number   NP19706


Effects of dissolved oxygen control on cell growth and exopolysaccharides production in batch culture of Agaricus blazei
Library Number   NP19713


Molecular weight and polydispersity estimation of adsorbing polymer brushes by atomic force microscopy
Library Number   NP19802


Getting the most for the effort...quickly
Library Number   NP19863


Photodegradation and photostability studies of Bendroflumethiazide (BFMT) in pharmaceutical formulations and urine samples by micellar liquid chromatography
Library Number   NP19873


Photodegradation and photostability studies of bendroflumethiazide in pharmaceutical formulations and urine samples by micellar liquid chromatography
Library Number   NP19887


Control of matrix effects in bioanalytical MS-MS using on-line multidimensional solid-phase extraction
Library Number   NP19890


Occurrence and specific congener profile of 40 polyhrominated diphenyl ethers in river and coastal sediments from Portugal
Library Number   WA31131


Atlantis HILIC Silica Columns Care and Use Instructions
Library Number  715000583


At-Column Dilution Application Notes
Library Number  71500078010


Waters MassPREP™ HILIC µElution Plate and Waters MassPREP™ Glycoanalysis Kit Care and Use Instructions
Library Number  715001013


Soft Drink Analysis SF36 Kit Care and Use Instructions
Library Number  715001314


AccQ Tag™ Ultra Derivatization Kit Care and Use Instructions
Library Number  715001331


ACQUITY UPLC™ HSS Column Care and Use Instructions
Library Number  715001429
The ACQUITY UPLC™ HSS packing materials were designed specifically for use with the Waters ACQUITY UPLC™ system and are manufactured in a cGMP, ISO 9001:2000 certified plant using ultra pure reagents. Each batch of ACQUITY UPLC™ HSS material is tested chromatographically withy acidic, basic and neutral analytes and the results are held to narrow specification ranges to assure excellent, reproducible performance. Every column is individually tested and a Performance Chromatogram and Certificate of Batch Analysis are provided on the eCord™ intelligent chip.


Waters Oasis Cartridges and 96-Well Plates Care and Use Instructions
Library Number  716001391
The Oasis family of solid-phase extraction products are designed to simplify and improve your sample preparation by combining the right sorbent chemistry, device format and methodology. There are five available Oasis® sorbent chemistries which are designed to meet just about all of your sample preparation needs. They are all built upon unique water-wettable Oasis® HLB copolymer and provide exceptional results. The sulfonic acid (MCX) and quaternary amine (MAX) derivatives of Oasis® HLB provide dual modes of retention, enabling greater cleanup selectivity and sensitivity for both acid and/or basic compounds — even if the sorbent in the wells runs dry. Oasis® WCX (weak cation exchanger) and WAX (weak anion exchanger) are also derivatives of Oasis® HLB. These sorbents are specifically designed to offer the same benefits and features as HLB with the ability to retain and release strong acids (e.g. sulfonates) and bases (e.g. quaternary amines). All of the five patented Oasis® chemistries are available in several device formats (e.g. cartridges, 96-well plate, and µElution plate) to meet your specific needs.


Waters AquaAnalysis System
Library Number  72000 2377EN
The AquaAnalysis System from Waters dramatically streamlines the water analysis process. Automated sample handling, proprietary column chemistries, and ultra-sensitive mass spectrometry detection have been combined into an on-line SPE/LC/MS/MS system that requires only a fraction of the typical sample volume. With our integrated system, operator interaction has been minimized – preparation and analysis times once measured in hours have been reduced to minutes.


Waters AquaAnalysis System
Library Number  72000%202377EN
The AquaAnalysis System from Waters dramatically streamlines the water analysis process. Automated sample handling, proprietary column chemistries, and ultra-sensitive mass spectrometry detection have been combined into an on-line SPE/LC/MS/MS system that requires only a fraction of the typical sample volume. With our integrated system, operator interaction has been minimized – preparation and analysis times once measured in hours have been reduced to minutes.


ESCi Multi-Mode Ionization Source
Library Number  720000104EN
For laboratories where multiple ionization techniques are required, the ESCi Multi-Mode Ionization Source for the ZQ Mass Detector minimizes the need for source changes and repeat injections. The ESCi Multi-Mode Ionization Source provides ESI and APCI in the same run, increasing analysis success for diverse samples.


OpenLynx Application Manager: Open Access Systems
Library Number  720000108EN
Maximum efficiency is essential for labs challenged by high throughput requirements and the management of data from a variety of mass spectrometry systems and users. To streamline mass spectrometry data acquisition, processing and reporting in conventional and open access laboratory environments, the Waters MassLynx 4.0 Software incorporates the OpenLynx Application Manager. OpenLynx Open Access Systems can: -Allow walk-up users to run routine LC/MS analyses -Maintain administrative control over Waters Mass Spectrometry Systems used by multiple individuals -Track the performance of open access systems -Facilitate batch processing and reporting of results


OpenLynx Global SERVER Application Manager
Library Number  720000109EN
Today''s research laboratories generate an unprecedented amount of information. To effectively deal with the complex and time-consuming process of managing and accessing this information, OpenLynx Global SERVER offers scientists a simple way to archive, review and mine their results. OpenLynx Global SERVER can: -Manage results from multiple Waters Mass Spectrometry Systems and laboratories -Archive and intelligently access the high volume of OpenLynx and FractionLynx Application Manager results generated in the laboratories -Provide accessibility of results to scientists and their colleagues within a laboratory or company


Waters Alliance Systems for Carbamate Analysis Brochure
Library Number  720000126EN
Waters Alliance System for Carbamate Analysis is a complete solution for carbamate analysis. With the Alliance System for Carbamate Analysis, you will successfully analyze your samples according to government regulations the first time, saving you time and money.


Performance Maintenance Options for Waters 2795 Separations Module
Library Number  720000134EN
The 2795 Separations Module is backed by a time/injections warranty covering the module and its components. This data sheet includes a reminder sticker for customers to place on their 2795 to remind them to call for a PM visit.


MassTrak LC/MS/MS Tacrolimus Kit
Library Number  7200001385EN


Alliance Systems for Ion Chromatography (IC) Analysis Performance Bulletin
Library Number  720000138EN
This 12-page performance bulletin, which has been updated to include the 2695 Separations Module, overviews the capabilities of Waters Alliance Systems for Ion Chromatography Analysis, highlighting the choices customers have when performing ion analysis. It addresses many of the concerns of an IC user and demonstrates the performance of the Alliance System in terms of linearity, precision, accuracy, sensitivity and reproducibility. It also shows the advantages of direct UV detection in ion analysis (EPA B-1011) and chemical suppression (EPA 300.0) with the addition of the Alltech ERISTM 1000HP Autosuppressor.


Waters PerformancePLUS Cartridge Check Valve System Data Sheet
Library Number  720000141EN
Waters PerformancePLUS Cartridge Check Valve System makes it faster, less expensive and easier than ever before to replace check valves, without compromising dependability and optimal performance. It is easy to use, cost efficient, designed to save time and extend component lifetime, durable and solvent resistant, as well as convenient and reliable. With its innovative features, the PerformancePLUS Cartridge Check Valve System enhances the reliability, convenience, uptime, and serviceability of Waters instrumentation. The PerformancePLUS Cartridge Check Valve System is one of Waters Quality Parts® and part of the Waters ConnectionsSM Program.


Electrospray Ionization-Atmospheric Pressure Chemical Ionization for use in Open Access, High Throughput LC/MS Applications
Library Number  720000168EN

Fast and accurate analytical methods are essential to keep pace with sample libraries produced from combinational chemistry and high throughput biological screening. Many laboratories now use a combination of ionisation techniques for the characterisation of these samples including Atmospheric Pressure Chemical Ionisation (APCI), Electrospray Ionisation (ESI) and Photoionisation (PI).

In this poster we present findings for a new combined APCI-ESI source, the Waters ESCi Multi-Mode Ionization Source, for use in HPLC applications. The combined source allows alternate on-line APCI-ESI scans within a single analysis. The performance of the combined source has been compared to the existing APCI and ESI interfaces and found to be equivalent.



YMC-Pack™ Pro™ Series of Columns
Library Number  720000173EN

The YMC-Pack™ Pro™ Series of HPLC Columns are the premier columns within the YMC column brand and have now expanded to include Hydrosphere C18™ and Pro C18™ RS columns. These columns offer a wide range of hydrophobicity and selectivity to assist you in method development and drug discovery. The YMC Pro™ Series of HPLC columns are based on a new generation of ultrapure silica with minimal metal content and novel Lewis acid / Lewis base endcapping for excellent peak shape and high efficiency. Each YMC column comes with a Certificate of Analysis.

Now, the YMC Pro™ Series has expanded to include Hydrosphere™ C18 (for hydrophilic compounds) and Pro C18 RS™ (for basic and large hydrophobic) columns. These new YMC column chemistries are designed to complement Pro C18™. With the addition of the Hydrosphere™ C18 and Pro C18 RS™ brands, the YMC Pro™ Series of columns are ideal for the analysis of all types of organic molecules but specifically basic and metal chelating compounds. The ultrapure silica and very low residual silanol activity means that these columns frequently do not require the use of ion-pair reagents or ion-suppression techniques, making them ideal for LC/MS applications.



LC/MS Quantification of 52 carbamates: a fully automated protocol
Library Number  720000176EN
--Carbamate, thiocarbamate, and urea-based pesticides are commonly used as agricultural pesticides. --They have demonstrated toxicological effects. Recently, they have been implicated as endocrine disruptors. --The field run-off water transports there analytes into the soil, ground water, and tributaries --Waste treatement does not remove ALL pesticides before discharge into the tributaries. --These are the source of YOUR drinking water. --There is a strong need for analytical methods to screen and quantify carbamates in raw agricultural commodites, drinking and surface water and soil. --The manufacturing waste of the carbamantes must be characterized prior to disposal. --US EPA Regulations ----Regulates pesticide use ----Requires routine monitoring of drinking water and raw source waters, soil and waste matrices ----Included the required routine EPA Method 531 (M531) for drinking and raw source water, 8318 is for soil and waste matrices


The Sentry Guard Column from Waters
Library Number  720000183EN
Sentry guard columns are ideal because they remove many impurities and extend the life of your column. The cartridge system allows for easy replacement. While many boast no loss in efficiency or peak symmetry, only one can actually increase your column’s performance. The Sentry guard column from Waters. Let it stand guard for you.


Millennium32 Software for Gas Chromatography
Library Number  720000185EN
This direct mailer promotes Waters Millennium32 Software for Gas Chromatography, the most versatile software developed for locating, generating, summarizing and reporting gas chromatography results. Millennium32 Software for Gas Chromatography is designed specifically for analytical chemists who need to effectively manage their gas chromatography data and improve the accuracy, productivity and security of their GC lab. In this mailer we focus on the following 5 questions or pain points that chemists may encounter with the gas chromatography software they are currently using, and how Millennium32 Software for Gas Chromatography overcomes these pain points: Are you struggling with the limitations imposed on you by your gas chromatography software? Do you need a flexible and easy way to locate, generate, report and communicate your gas chromatography data? Do you spend hours performing repetitive, manual calculations? Do you spend unnecessary time and effort to obtain your final laboratory report? Can you easily track and trend your laboratory results without having to use third party software?


Mining Urinary Proteome Using an Alternative MS Data Acquitistion Approach and a Novel Database Search Algorithm
Library Number  7200001940EN


626 LC System brochure
Library Number  720000198EN
The Waters 626 LC System combines advanced polymeric technology and low dispersion system volume into a single liquid chromatograph that provides the highest level of performance available in a non-metallic system. The 626 LC System is designed to accommodate a wide variety of life science applications including high-resolution protein purification, microbore peptide mapping, nucleic acid isolations, and purification and analysis of oligosaccharides.


2414 Differential Refractive Index Detector Brochure
Library Number  720000199EN
Waters 2414 dRI detector redefines the standard of excellence for refractive index detectors. With unsurpassed sensitivity, stability and reproducibility, the 2414 detector is the ideal solution for analysis of components with limited or no UV absorption such as alcohols, sugars, saccarides, fatty acids and polymers.


GPC Column Wall Chart
Library Number  720000205EN
This wall chart highlights the 3 families of Styragel® columns (HR, HT and HMW), and contains the usable molecular weight range of each pore size. It also provides information on solvent compatibility with a wide variety of polymers.


Waters Alliance GPC 2000 Series System
Library Number  720000209EN


2465 Pulsed Electrochemical Detector specifications
Library Number  720000211EN
Waters 2465 detector combines reliability, simplicity and performance for research and development applications. The 2465 detector allows DC, pulse and scan modes of operation for analyzing a wide range of compounds. The 2465 detector is ideal for use with Waters Alliance Systems with Empower Software.


A HIGH-THROUGHPUT LC/MS/MS METHOD FOR TACROLIMUS MEASUREMENT IN KIDNEY AND LIVER TRANSPLANT PATIENTS
Library Number  7200002125EN


Waters 515 HPLC Pump
Library Number  720000220EN


Breeze HPLC System
Library Number  720000227EN


ZQ Mass Detector for API LC/MS specifications
Library Number  720000234EN
Waters ZQ Mass Detector, a single quadrupole, benchtop mass spectrometric detector, offers unsurpassed sensitivity and ruggedness in a compact design for smaller, faster, better API LC/MS.


ZQ and Quattro micro API Benchtop Quadrupole Mass Spectrometers.
Library Number  720000246EN
Pushing the boundaries of productivity and efficiency in a knowledge-driven environment, the Waters Micromass ZQ Mass Detector and the Micromass Quattro micro API Mass Analyzer provide unprecedented capabilities for increasing laboratory throughput. Furthering their shared strengths both benchtop mass spectrometers are driven by MassLynx 4.0 Software, the market-leading LC/MS software for acquiring, analyzing and managing mass spectrometry information. The ZQ and the Quattro micro API help scientists keep up with the steady flow of samples into laboratories by: -Increasing throughput in the same laboratory space -Reducing training overhead -Generating sample knowledge and not just data -Providing task-specific usability for laboratory instruments


Waters Alliance Dissolution System Brochure
Library Number  720000251EN
For pharmaceutical chemists who develop methods or monitor drug quality with dissolution testing, Waters Alliance Dissolution System delivers a superior level of quality and productivity by combining highly precise and reliable, automated on-line sample acquisition with the unmatched performance of Alliance system technology. Transfers samples directly from single or dual dissolution baths to vials inside the Waters 2695D Separations Module for enhanced reproducibility, consistent performance, optimal throughput, and higher quality results Ideal for high throughput analysis such as immediate and controlled-release formulations Offers automated routines that provide documented evidence of quality results Fits on a standard laboratory bench


2465 Electrochemical Detector
Library Number  720000265EN
Waters 2465 Electrochemical Detector combines sensitivity, reliability and simplicity to deliver the best electrochemical detection performance on the market today.


2487 Dual Wavelength Absorbance Detector brochure
Library Number  720000266EN
Waters 2487 Detector is the most sensitive and versatile absorbance detector for HPLC. Designed to provide the highest performance in UV/Vis detection, the 2487 detector offers the superior sensitivity required for detection of minor impurities, with the linear dynamic range to simultaneously quantitate major and minor components for both routine and complex applications.


2487 Dual Wavelength Absorbance Detector specifications
Library Number  720000267EN


MUX-technology for the Waters ZQ Mass Detector Toss Sheet
Library Number  720000325EN
Automated, parallel LC/MS analysis using MUX-technologyTM is now available with Waters ZQTM Mass Detector--the industry''s finest API single quadrupole detector. Specifically designed to meet the challenge of sample throughput bottlenecks, Waters ZQ Mass Detector with MUX-technology maximizes analytical throughput, reduces cycle time by a factor of 4 and accelerates analysis time--all delivering enhanced productivity.


Connections Compliance Services Brochure
Library Number  720000328EN
Connections Compliance Services are designed to assist Waters customers in achieving regulatory compliance for their HPLC, UPLC and LC/MS systems. Connections Compliance Services include:
- Instrumentation qualification and calibration services
- Software qualification services
- Computer hardware qualification services
- Self-directed qualification tools and accessories
- Educational services


515 pump spec sheet
Library Number  720000336EN
The Waters 515 HPLC pump combines the most important aspects of HPLC performance -- accuracy, precision, reliability and pulse-free eluent delivery. An easy-to-read display and keypad interface enable error free programming


Quattro micro API Tandem Quadrupole System
Library Number  720000338EN
The Quattro microTM API overcomes these challenges in analytical LC/MS/MS: -Need for intelligently optimized systems -Pressure to meet increasing throughput targets -Necessity to rapidly cross-train analysts -Demand for better sensitivity and Limits of Quantification -Requirement to operate in a 21 CFR 11 environment Networked sample to knowledge converters like the Quattro micro API are a fusion of compact, intelligent mass analyzers and client/server Mass-InformaticsTM operating within the global e-MSTM workspace. The Quattro micro API incorporates the finest high precision tandem quadrupole mass analyzer technology, with a m/z range of 2 - 2000 as standard. Measuring only 1/3 of the width of existing instruments, the Quattro micro API also saves significant linear bench space.


Waters 717plus Autosampler Brochure
Library Number  720000340EN


2996 PDA Detector specifications
Library Number  720000350EN
The Waters 2996 PDA Detector offers no-compromise chromatographic and spectral sensitivity, reliability and ease of use for preparative and analytical separations.


2488 Multichannel UV/Vis Detector Brochure
Library Number  720000353
Analyze more samples in less time with Waters® 2488 Multichannel UV/Vis detector, the first true multiple flow cell, continuously monitored UV/Vis detection system. The optical detection capabilities of the Waters 2488 Multichannel UV/Vis detector were specifically designed to complement the Waters Micromass line of LC/MS technologies such as the Waters Micromass LCT™, Waters Quattro micro™ or the Waters ZQ™ Mass Spectrometer with MUX-technology.


2695 Separations Module specifications
Library Number  720000357EN
The Waters 2695 XE Separations Module, part of the Alliance System, offers an integrated configuration for solvent and sample management that meets stringent user expectations.


2795 Separations Modules specifications
Library Number  720000358EN
Waters 2795 Separations Module, based on the integrated configuration for solvent XYZ sample management with parallel processing software pioneered in the 2790 XE Separations Module, has been augmented through design innovations to meet more stringent expectations.


Waters Solvent Selector Valve
Library Number  720000363EN



Library Number  720000364EN


Waters Six-Column Selector Valve
Library Number  720000368EN


Alliance HPLC Systems
Library Number  720000370EN
Waters Alliance HPLC Systems have been continually expanded and perfected over the years to accommodate an enormous range of real-world, problem-solving HPLC separation challenges. Synonymous with dependable performance, high quality, and flexible operation, tens of thousands of these systems are bing used every day. Alliance HPLC Systems meet the rigorous requirements of routine analyses in addition to the performance standards of new-product research and method development. Whether your lab operates in the pharmaceutical, chemistry, food safety, environmental , or quality control arenas, Alliance HPLC Systems offer you a proven solution for all of your HPLC requirements.


2996 PDA Detector Brochure
Library Number  720000372EN
Waters 2996 PDA Detector incorporates uniquely-integrated software and optics innovations that deliver no-compromise chromatographic and spectral sensitivity, reliability and ease of use. Look for new features including 2D capabilities and a new flowcell design.


2475 Multi- Wavelength Fluorescence Detector specifications
Library Number  720000377EN
The Waters® 2475 Multi-Wavelength Fluorescence Detector offers unsurpassed sensitivity for quantitating low concentrations of target compounds, whether naturally fluorescent or derivatized with a fluorescent tag. The 2475 detector sets the standard for fluorescence detection with 3-D and “on-the-fly” spectral scanning for emission and excitation, on-board wavelength accuracy verification with available comprehensive qualification methods and the ability to monitor up to four independent wavelength pairs.


Waters Industry Solutions: Nutraceuticals
Library Number  720000379EN
Nutraceutical capabilities brochure (12 pages) highlighting complete HPLC and LC/MS system solutions aimed at meeting the needs of the nutraceutical marketplace. Areas covered include analyzing extracts and ingredients, monitoring contaminants and adulterants, isolate compound sand purify standards and supporting manufacturing and quality control. Nutraceuticals are defined in this brochure as dietary supplements, natural products and functional foods.


Waters PAH Columns Improve Analysis of PAH Compounds
Library Number  720000382EN
Polynuclear Aromatic Hydorcarbons (PAHs) are among the most frequently monitored environmental contaminants. Waters PAH columns are optimized for the HPLC analysis of PAHs. These columns achieve baseline resolution and excellent peak symmetry for 16 different target analytes in less than 25 minutes (refer to the chromatogram for details), while employing a simple water/acetonitrile binary gradient method. The resolving power of the PAH columns provides superior peak shape identification and quantitation for PAHs. Waters PAH columns come in seven different dimensions (including a capillary format) and two particle sizes.


XTerra Falcon Poster
Library Number  720000383EN
The creative selection is the Peregrine Falcon. The falcon is the fastest living creature in the world and it has extraordinary visual resolution - eight times that of humans seeing at 160 feet what a person sees at 20. XTerra® Columns give you the widest range of separation chemistries, column dimensions, and particle sizes for optimal methods and high throughput. The Falcon and XTerra® columns both deliver the perfect combination of Speed and Resolution!


XTerra Flamingo Poster
Library Number  720000384EN
Phoeniconaias minor, the lesser flamingo represents Extreme Life. Amazingly adaptive, the flamingo lives in the harsh environment of East African Soda lakes. To feed, it migrates north in the Rift Valley, seeking shallow, caustic water at the optimum pH (10.4-10.5) for supporting the growth of its favorite food: blue-green algae. This primary food source provides the brilliant pink pigment in the flamingo''s feathers. XTerra® Columns - Extreme Lifetime. Waters'' new Hybrid Particle Technology allows customers to operate routinely under whatever conditions are required for optimal selectivity - wider pH range (1-12). Nature equips the lesser flamingo to thrive in extreme conditions. Hybrid Particle Technology equips XTerra® columns for extreme performance in successful drug separations.


2414 Refractive Index Detector specifications
Library Number  720000385EN
Waters 2414 dRI detector defines the standard of excellence for chromatographic analysis.


HPLC and GPC System Solutions: Polymer Characterization capabilities brochure
Library Number  720000386EN
This 12-page polymer characterization capabilities brochure details the HPLC and GPC systems, software and chemistries that Waters provides for the following polymer characterization applications using room temperature GPC, gradient HPLC, and high temperature GPC. Polyolefins Elastomers Copolymers Nylons/Polyesters Aqueous Polymers Polycarbonates Additives Polymer Blends


2767 Sample Manager specifications
Library Number  720000389EN
For chemists, lab managers or technicians working within the pharmaceutical, industrial and life sciences industries who are involved in molecular isolation and purification, the Waters MS-based and UV-based Autopurification Systems increase sample throughput, simplify the automated purification process, maximize efficiency, and expedite the discovery and development cycle.


Millennium32 4.0 Software Upgrade Brochure
Library Number  720000391EN
This 2-page data sheet promotes the key benefits of Millennium32 4.0 Software and provides information on how to obtain an upgrade kit for this new software version.


2695 Separations Module Performance Bulletin
Library Number  720000397EN
This 12-page performance bulletin overviews the capabilities of the Waters Alliance HPLC System and the 2695 Separations Module. It addresses many of the concerns of the HPLC user: maintaining high performance, minimizing downtime, resolving training issues, complying with regulatory requirements and reaching maximum productivity. This piece demonstrates the performance of the Alliance System by providing examples of high sensitivity, throughput and reproducibility without compromising ease of use, reliability and accuracy.


2700 Sample Manager specifications
Library Number  720000398EN
For chemists, lab managers or technicians working within the pharmaceutical, industrial and life sciences industries who are involved in molecular isolation and purification, the Waters MS-based and UV-based Autopurification Systems increase sample throughput, simplify the automated purification process, maximize efficiency, and expedite the discovery and development cycle.


2747 Sample Manager specifications
Library Number  720000399EN
For chemists, lab managers or technicians working within the pharmaceutical, industrial and life sciences industries who are involved in molecular isolation and purification, the Waters MS-based and UV-based Autopurification Systems increase sample throughput, simplify the automated purification process, maximize efficiency, and expedite the discovery and development cycle.


2475 Multi-Wavelength Fluorescence Detector Data Sheet
Library Number  720000401EN
The Waters® 2475 Multi-ë Fluorescence Detector offers unsurpassed sensitivity for quantitating low concentrations of target compounds, whether naturally fluorescent or derivatized with a fluorescent tag. The 2475 detector sets the standard for fluorescence detection with 3-D and “on-the-fly” spectral scanning for emission and excitation, on-board wavelength accuracy verification with available comprehensive qualification methods and the ability to monitor up to four independent wavelength pairs.


432 Conductivity Detector brochure
Library Number  720000405EN


XTerra - Säulen
Library Number  720000424DE
The Most Successful Column in Over 30 Years of Stationary Phase Technology The universal acceptance by pharmaceutical scientists in drug discovery, method development and isolation and purification has enabled XTerra® columns to become the fastest selling and most successful column product in the world of chromatography. The reason: the enabling science of Hybrid Particle Technology. Drug discovery scientists benefit from the DMSO injection-resistance of the rugged XTerra® particle. Method development scientists are able to operate at whatever pH is necessary for optimal selectivity due to XTerra® columns’ wide pH range. Isolation and purification scientists can load up to 60x more material per injection because of the high mass loading capacity of XTerra® columns.


XTerra Columns Brochure
Library Number  720000424EN
The Most Successful Column in Over 30 Years of Stationary Phase Technology The universal acceptance by pharmaceutical scientists in drug discovery, method development and isolation and purification has enabled XTerra® columns to become the fastest selling and most successful column product in the world of chromatography. The reason: the enabling science of Hybrid Particle Technology. Drug discovery scientists benefit from the DMSO injection-resistance of the rugged XTerra® particle. Method development scientists are able to operate at whatever pH is necessary for optimal selectivity due to XTerra® columns’ wide pH range. Isolation and purification scientists can load up to 60x more material per injection because of the high mass loading capacity of XTerra® columns.


Columnas XTerra
Library Number  720000424ES
The Most Successful Column in Over 30 Years of Stationary Phase Technology The universal acceptance by pharmaceutical scientists in drug discovery, method development and isolation and purification has enabled XTerra® columns to become the fastest selling and most successful column product in the world of chromatography. The reason: the enabling science of Hybrid Particle Technology. Drug discovery scientists benefit from the DMSO injection-resistance of the rugged XTerra® particle. Method development scientists are able to operate at whatever pH is necessary for optimal selectivity due to XTerra® columns’ wide pH range. Isolation and purification scientists can load up to 60x more material per injection because of the high mass loading capacity of XTerra® columns.


Colonnes XTerra
Library Number  720000424FR
The Most Successful Column in Over 30 Years of Stationary Phase Technology The universal acceptance by pharmaceutical scientists in drug discovery, method development and isolation and purification has enabled XTerra® columns to become the fastest selling and most successful column product in the world of chromatography. The reason: the enabling science of Hybrid Particle Technology. Drug discovery scientists benefit from the DMSO injection-resistance of the rugged XTerra® particle. Method development scientists are able to operate at whatever pH is necessary for optimal selectivity due to XTerra® columns’ wide pH range. Isolation and purification scientists can load up to 60x more material per injection because of the high mass loading capacity of XTerra® columns.


XTerra Columns - Japanese Version
Library Number  720000424JA
The Most Successful Column in Over 30 Years of Stationary Phase Technology The universal acceptance by pharmaceutical scientists in drug discovery, method development and isolation and purification has enabled XTerra® columns to become the fastest selling and most successful column product in the world of chromatography. The reason: the enabling science of Hybrid Particle Technology. Drug discovery scientists benefit from the DMSO injection-resistance of the rugged XTerra® particle. Method development scientists are able to operate at whatever pH is necessary for optimal selectivity due to XTerra® columns’ wide pH range. Isolation and purification scientists can load up to 60x more material per injection because of the high mass loading capacity of XTerra® columns.


Waters XTerra Columns-Korean version
Library Number  720000424KO
The Most Successful Column in Over 30 Years of Stationary Phase Technology The universal acceptance by pharmaceutical scientists in drug discovery, method development and isolation and purification has enabled XTerra® columns to become the fastest selling and most successful column product in the world of chromatography. The reason: the enabling science of Hybrid Particle Technology. Drug discovery scientists benefit from the DMSO injection-resistance of the rugged XTerra® particle. Method development scientists are able to operate at whatever pH is necessary for optimal selectivity due to XTerra® columns’ wide pH range. Isolation and purification scientists can load up to 60x more material per injection because of the high mass loading capacity of XTerra® columns.


XTerra Columns - Traditional Chinese Version
Library Number  720000424ZH
The Most Successful Column in Over 30 Years of Stationary Phase Technology The universal acceptance by pharmaceutical scientists in drug discovery, method development and isolation and purification has enabled XTerra® columns to become the fastest selling and most successful column product in the world of chromatography. The reason: the enabling science of Hybrid Particle Technology. Drug discovery scientists benefit from the DMSO injection-resistance of the rugged XTerra® particle. Method development scientists are able to operate at whatever pH is necessary for optimal selectivity due to XTerra® columns’ wide pH range. Isolation and purification scientists can load up to 60x more material per injection because of the high mass loading capacity of XTerra® columns.


Automated Method Development System Brochure
Library Number  720000429EN


2757 Sample Manager specifications
Library Number  720000432EN
The 2757 Sample Manager is a high-capacity fraction collecting system that easily and automatically manages the collection of purified peak fractions from any HPLC or LC/MS system under MassLynx Software control.


717+ AutoSampler specifications
Library Number  720000435EN


2757 Sample Manager
Library Number  720000436EN
The 2757 Sample Manager is a high-capacity fraction collecting system that easily and automatically manages the collection of purified peak fractions from any HPLC or LC/MS system under MassLynx Software control.


2747 Sample Manager Brochure
Library Number  720000440En
The Waters 2747 Sample Manager is a high capacity, robotic autosampler that manages the injection of samples from microplates, test tubes and 4ml vials and conventional autosampler vials. The 2747 can be configured with one or two analytical or preparative injectors.


Empower Software (v1)
Library Number  720000441EN

This brochure describes Empower Software''s powerful features, that make it easy to focus on running samples and producing meaningful results. With enhanced 21 CFR Part 11 compliance capabilities, Empower Software takes data integrity, advanced security, audit trails and reporting to an unparalleled level. Multiple user interfaces allow scientists to choose the one most appropriate to the analysis they are performing.

Empower Software is part of the Waters Laboratory Informatics suite.



Waters HSPgel Columns for Fast GPC Analysis
Library Number  720000444EN
Waters HSPgel Columns: for fast GPC analysis. These columns provide accurate and precise molecular weight determinations in under 7 minutes. The HSPgel columns data sheet highlights the major product benefits includes ordering information.
- Fast, accurate and precise molecular weight polymer determinations
- Increased sample throughput
- Greatly decrease solvent consumption and disposal

The combination of HSPgel columns, Alliance solvent management and Millennium GPC software results in fast, accurate and precise molecular weight polymer determinations.


Symmetry Family of Columns
Library Number  720000454EN
Columns for every step in the drug discovery process: --Superior peak shape --Unmatched reproducibility --Extended column lifetime --Fast analysis without sacrificing resolutionn --Direct scale up from analytical to prep --Design for LC/MS


Columnas Symmetry para HPLC
Library Number  720000454ES


432 Conductivity Detector specifications
Library Number  720000463EN


The Oasis µElution Plate- Waters Newest Innovation in SPE Technology
Library Number  720000467EN
The new Oasis® µElution plate combines patented* plate design, proven Oasis® chemistries, and generic protocols enabling elution volumes as low as 25 µL. Now for the first time you can perform SPE clean-up and concentration of very small sample volumes. Achieve superior results compared to protein precipitation in the same or less time using the Oasis® µElution Plate. This plate produces extracts that can be directly injected, eliminating the time-consuming evaporation step. Eluting in 25 µL without evaporation provides up to 15x increase in sample concentration, enabling sensitive, robust, and reproducible SPE results. Scientists in both drug discovery and drug development can prepare biological samples for LC/MS/MS analysis using a more efficient, generic methodology and can successfully eliminate the time consuming evaporation step with the new Oasis® µElution plate.


Rapigest™ SF Toss Sheet
Library Number  720000468EN
Waters has introduced a new reagent, RapiGest™ SF, that dramatically improves in-solution enzymatic protein digestion in terms of speed and peptide recovery. RapiGest™ SF is available in 1 or 10mg vials containing enough material for 1-10 digestions. RapiGest™ SF will not modify protiens/peptides,suppress endoproteases, or interfere with HPLC, MALDI-TOF MS or HPLC/MS techniques. Many hydrophobic proteins are resistant to proteolysis because their cleavage sites are inaccessible to endoproteases. RapiGest™ SF is a mild denaturant that solubilizes and unfolds the substrate protein, making it more amenable to cleavage. RapiGest SF features and benefits include: - Increases peptide recovery and coverage - Facilitates the digestion of proteolytically resistant proteins - Increases solubility of hydrophobic proteins/peptides - Compatible with MALDI, ESI, HPLC - Acidic conditions break down RapiGest SF to non-interfering by-products - Does not suppress peptide ionization -RapiGest SF shows significant advantage over other denaturants since it is not disruptive to endoprotease activity -Allows use of lesser amounts of expensive endoproteases -Is effective in Asp-N, Glu-C, Lys-C, and chymotrypsin digestions -Significantly decreases proteolytic digestion time -Enables same day digestions and analysis


MassLynx 4.0 Software Upgrade data sheet
Library Number  720000469EN
This datasheet includes information and system requirements for upgrading to MassLynx 4.0 Software.


Customizable Dissolution Reporting Features
Library Number  720000470EN
The fully-automated Waters® Alliance® Dissolution System has the versatility of performing online dissolution testing complete with calculations and customizable reports. Waters Empower Software helps you accomplish more in less time by turning your raw data into reliable answers using new dissolution reporting features.


Atlantis ® Columns Applications Notebook
Library Number  720000472EN
The Atlantis® Columns Applications Notebook contains an Introduction to polar retention, 82 individual HPLC and LC/MS applications, Troubleshooting and Problem-Solving Tables, Column Care and Use Instructions, and a Product Ordering Information section.


Introduction to Atlantis Columns [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN-1
An introduction to polar retention


Atlantis Columns Care and Use Instructions [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN-2
A comprehensive manual for using Atlantis columns on an HPLC system.


Troubleshooting and Problem Solving Using Atlantis Columns[Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN-3
A table which lists common problems, impact, solutions and benefits.


Acyclovir- Isocratic Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.01
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Acyclovir- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.02
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Amoxicillin- Isocratic Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.03
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Amoxicillin- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.04
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Analgesics- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.05
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Anesthetics- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.06
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Arbutin- Isocratic Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.07
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Aromatic Acids- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.08
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Aromatic Amino Acids- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.09
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


100% Aqueous QC Batch Test- Isocratic Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.10
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Steroids - 2.1 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.100
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Steroids - 4.6 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.101
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Sulfonamides - 2.1 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.102
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Sulfonamides - 4.6 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.103
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Sulfonamides - Analytical to Preparative Scale Up [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.104
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Sulfonamides - Analytical to Preparative Scale Up [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.105
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Water and Fat Soluble Vitamins [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.106
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Water and Fat Soluble Vitamins - Analytical to Preparative Scale Up [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.107
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Beta Blockers- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.11
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Catechins- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.12
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Catecholamines- Isocratic Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.13
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Catecholamines- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.14
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Cold Medicine Products- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.15
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Cytochrome C Tryptic Digest- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.16
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Diuretics- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.17
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Drugs for Rhinitis- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.18
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Ginsenosides- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.19
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Lipid Soluble Antioxidants- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.20
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Nalidixic Acid Antibiotics- Isocratic Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.21
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Nalidixic Acid Antibiotics- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.22
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Nalidixic Acid Antibiotics- LC/MS Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.23
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Nucleic Acids- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.24
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Nucleosides- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.25
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Organic Acids- Isocratic Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.26
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Oxidative Stress Markers- pH 3.0[Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.27
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Oxidative Stress Markers- 10% MeOH, pH 5.0[Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.29
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Paclitaxel- Isocratic Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.30
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Peptides- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.31
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Phthalic Acids- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.32
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Phthalic Esters- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.33
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Polar and Non-Polar Compounds Test Mix [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.34
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Polar and Non-Polar Compounds Test Mix [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.35
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Polar and Non-Polar Compounds Test Mix [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.36
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Polar and Non-Polar Compounds Test Mix [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.37
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Polar Pesticides- LC/MS [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.38
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Purine Alkaloids- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.39
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Sulfonamides- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.40
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Vancomycin- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.41
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Water Soluble Vitamins- Gradient Separation [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.42
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Retaining Polar Compounds [Excerpt From Atlantis® Columns Applications Notebook]
Library Number  720000472EN.60
A decision map to help you select an appropriate column for retention of polar compounds.


Acephate in River Water [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.61
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, SPE Method & recovery data, and Analytical Results.


Acetylcholine and Choline [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.62
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Acrylamide [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.63
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Allantoin [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.64
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Aminoglycoside Antibiotics [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.65
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Asulam in River Water [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.66
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, SPE Method, and Analytical Results. Part Number for Oasis MCX Extraction Cartridge: 186000255


Bamethan and Albuterol - LC/MS [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.67
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Bamethan and Albuterol - LC/UV; HILIC vs. Reversed-Phase [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.68
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Bamethan and Albuterol in Plasma - LC/MS [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.69
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Beta-Blockers - Analytical to Preparative Scale Up [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.70
This Application Includes Prep HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Catecholamines - HILIC [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.71
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Catecholamines - LC/ECD [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.72
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Clonidine [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.73
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Dextromethorphan and N-Dealkylated Metabolite [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.74
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Diazepam and Hydroxlated Metabolite [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.75
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results


Fluoroquinolone Antibiotics in Beef Kidney [LC/MS/MS] [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.76
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, SPE method, and Analytical Results.

Oasis MAX Cartridge Part Number is 186000369


Guanine and Acyclovir -- HILIC vs. Reversed-Phase [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.77
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Guanine and Acyclovir -- HILIC vs. Reversed-Phase [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.78
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Morphine and Morphine-3-beta-D-Glucuronide -- HILIC vs. Reversed-Phase [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.79
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Nalidixic Acid Antibiotics by LC/MS - 1.0 Minute Gradient [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.80
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Nalidixic Acid Antibiotics by LC/MS - 2.0 Minute Gradient [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.81
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Nalidixic Acid Antibiotics by LC/MS - 3.0 Minute Gradient [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.82
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Nalidixic Acid Antibiotics by LC/MS - 5.0 Minute Gradient [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.83
This Application Includes LC/MS System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Nalidixic Acid Antibiotics - Isocratic [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.85
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Nucleic Acid Bases -- Gradient Effect of Polar Solvent on Retention in HILIC [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.86
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Nucleic Acid Bases -- HILIC vs. Reversed-Phase [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.87
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Nucleic Acid Bases -- Isocratic [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.88
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Phenones -- 2.1 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.89
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Phenones -- 4.6 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.90
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Polar and Non-Polar Compounds - Analytical to Preparative Scale Up [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.91
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Polar and Non-Polar Compound Test Mix -2.1 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.92
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Polar and Non-Polar Compound Test Mix -4.6 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.93
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Profens - Gradient -4.6 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.98
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Profens - Isocratic -4.6 x 20 mm IS Column [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472EN.99
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, and Analytical Results.


Oxidative Stress Markers- pH 5.0 [Excerpt From Atlantis™ Columns Applications Notebook]
Library Number  720000472N.28
This Application Includes HPLC System Conditions, Sample Chromatogram, Analyte Structures, USP Tailing Factors, and Analytical Results.


Q-Tof micro Mass Spectrometer brochure
Library Number  720000478EN
This 8-page brochure highlights the features and benefits of the Waters® Micromass® Q-Tof micro™ Mass Spectrometer. Whether scientists want to identify and characterize proteins or perform structural elucidation of small molecules, exact mass measurement is as important as having the sensitivity to detect them. The Waters Micromass Q-Tof micro Mass Spectrometer enables scientists to combine sensitive LC/MS/MS with simple, automated exact mass measurement, increasing confidence in their results. The high quality data delivered by the Q-Tof micro can provide information on elemental composition, structural characteristics and excellent specificity for identifying scientists'' compounds in complex matrices. With the Q-Tof micro Mass Spectrometer scientists can: -Determine elemental composition -Elucidate structural characteristics -De novo sequence peptides with the highest confidence -Eliminate false positive protein identification -Identify components in complex matrices -Distinguish between nominally isobaric amino acids


Evaluation of the Quattro micro for the quantification of Diazepam in Human Plasma
Library Number  720000485EN


Evaluation of the Quattro micro for the Quantitation of Drug Substances in Cell Culture Medium.
Library Number  720000486


Empower Software for the ZQ Mass Detector
Library Number  720000487EN
Incorporate HPLC and routine mass detection into your chromatographic system -- and increase your confidence in analytical results -- by using Empower Software to control and acquire data with the ZQ Mass Detector.


Ensuring Soft Drink Consistency and Quality with HPLC
Library Number  720000488EN
Ensuring Soft Drink Consistency and Quality with HPLC focuses on the use of a Waters Breeze System in the soft drink bottling process to ensure quality. A complete package consisting of system, chemistries, methodology, standards and pre-formulated mobile phase for this industry is discussed.


ProteinLynx Global SERVER 2.0 Application Manager: Total Protein Mass-informatics
Library Number  720000490EN
ProteinLynx Global SERVER 2.0 is the post-genomic software platform for accelerated proteomics research. Providing a smarter way to overcome these proteomics challenges, ProteinLynx Global SERVER 2.0: -Reduces ambiguous protein identification by MS -Extracts useful knowledge from complex databases -Minimizes raw data overload in laboratories -Overcomes lack of resources for manual data interpretation -Integrates and manages data/results from multiple technologies


Empower Software: ApexTrack Integration - Theory and Application
Library Number  720000494EN
This white paper addresses the peak integration algorithm, ApexTrack, in Empower and Empower 2 Software.


Using Advanced Qualification Technologies to Meet the Changing Landscape of Regulatory Compliance
Library Number  720000498EN


Empower Software: Chemical Structures Option
Library Number  720000504EN
This white paper addresses the chemical structures option in Empower Software. This option allows you to place chemical structures on your spectral and chromatographic plots as well as the ability to fully document and retrieve structural information related to your analyses.


Educational Services Course Catalog Germany 2007
Library Number  720000508DE

New for 2007, our course catalog, listing course descriptions, locations, and dates for Germany.

Our customer education course catalog lists UPLC, HPLC, MS and software courses currently offered by Waters Educational Services. The courses are categorized by topic, and include a complete description and part number for easy registration.

Course areas include Laboratory Informatics, UPLC Technology, Operation and Maintenance, MS Technologies, Compliance, and General Chromatography.



Waters Educational Services 2008 Course Catalog, North America
Library Number  720000508EN
NEW for 2008 - The Waters Educational Services course catalog!

Our customer education course catalog lists all LC and MS courses currently offered by Waters. The courses are categorized by topic and include a complete description and part number for easy registration.

Course areas include Laboratory Informatics, UPLC, Operation and Maintenance, MS Technologies, Compliance and General Chromatography.


Waters Educational Services Course Catalog, Spain
Library Number  720000508ES

Our course catalog lists course descriptions, locations, and dates for Spain.

Our customer education course catalog lists UPLC, HPLC, MS and software courses currently offered by Waters Educational Services. The courses are categorized by topic, and include a complete description and part number for easy registration.

Course areas include Laboratory Informatics, UPLC Technology, Operation and Maintenance, MS Technologies, Compliance, and General Chromatography.



Waters Educational Services Course Catalog, France
Library Number  720000508FR

Our course catalog lists course descriptions, locations, and dates for France.

Our customer education course catalog lists UPLC, HPLC, MS and software courses currently offered by Waters Educational Services. The courses are categorized by topic, and include a complete description and part number for easy registration.

Course areas include Laboratory Informatics, UPLC Technology, Operation and Maintenance, MS Technologies, Compliance, and General Chromatography.



Waters Educational Services 2006 course catalog, Benelux
Library Number  720000508NL

New for 2006, our course catalog, listing course descriptions, locations, and dates for the BeneLux region.

Our customer education course catalog lists UPLC, HPLC, MS and software courses currently offered by Waters Educational Services. The courses are categorized by topic, and include a complete description and part number for easy registration.

Course areas include Laboratory Informatics, UPLC Technology, Operation and Maintenance, MS Technologies, Compliance, and General Chromatography.



Capillary Electrophoresis-MS and Tandem MS for the Identification of Non-Steroidal Anti-Inflammatory Drugs and their Metabolites in Human Urine
Library Number  720000514EN


DNA-Adduct Analysis by NanoFlow Electrospray
Library Number  720000516EN


The Analysis Of Organometallic Compounds Using ElectrosprayIonization Mass Spectrometry
Library Number  720000517EN


Accurate Mass Determination of Narrow Electrophoretic Peaks using an Orthogonal Acceleration Time of Flight Mass Spectrometer
Library Number  720000518EN


Analysis of Polychlorinated Biphenyls (PCBs) by GC High Resolution Mass Spectrometry using the AutoSpec Ultima NT
Library Number  720000520EN


Validation of a Bioanalytical Method for Measurement of Alprazolam in Human Plasma
Library Number  720000521EN
This report describes the validation of a high performance liquid chromatography-tandem mass spectrometry (HPLC/MS/MS) procedure for the measurement of alprazolam in human plasma. Tandem MS with liquid chromatography offers an integrated solution for bioanalyltical studies as it generates accurate and unambiguous data.


Opiates: Use or Abuse? Quantification of Opiates in Human Urine.
Library Number  720000522EN


Empower 2 Software: Attaching chemical structures to chromatograms and spectra for presentation
Library Number  720000523EN
This datasheet provides details about Empower 2 Software''s enhanced presentation option for working with and attaching chemical structures to reports for presentation.


Waters Chemistry Operations: The World Leader in Separation Sciences
Library Number  720000525EN

Separations are central to scientific practice throughout the world. Achieving the highest quality separations -- whether the critical need is sample enrichment, isolation, purity, throughput, or information about chemical structure or composition -- demands not only the best technology, the full set of capabilities that Waters offers to deliver that technology to you in a way that ensures your success.

Highlights of this brochure include:
-Waters Customer Commitment Statement
-A Tradition of Innovation and Excellence
-Recent Innovations
-Providing Separations Solutions
-Manufacturing the Waters way
-Extraordinary Quality, World-Class Support



Waters Chemistry Operations: The World Leader in Separation Sciences (International Version)
Library Number  720000526EN

Separations are central to scientific practice throughout the world. Achieving the highest quality separations -- whether the critical need is sample enrichment, isolation, purity, throughput, or information about chemical structure or composition -- demands not only the best technology, the full set of capabilities that Waters offers to deliver that technology to you in a way that ensures your success.

Highlites of this brochure include:
-Waters Customer Commitment Statement
-A Tradition of Innovation and Excellence
-Recent Innovations
-Providing Separations Solutions
-Manufacturing the Waters way
-Extraordinary Quality, World-Class Support



ChromaLynx Application Manager
Library Number  720000529EN
From the development and QC of flavor and fragrance compounds to the study of plant metabolism to identify the effects of genetic modification, there is a need to qualitatively and semi-quantitatively analyze complex mixtures. Manually reviewing complex chromatograms to locate potentially significant components is a laborious, time-consuming and subsequently expensive task that can be only partially successful since closely eluting components are often missed. By using Waters ChromaLynx™ Application Manager (one in the family of MassLynx™ Software''s Application Managers that streamline application-specific data acquisition and processing), GC/MS and GC/MS/MS data processing can be automated allowing for rapid detection, identification and semi-quantitative determination of all components with confidence.


TargetLynx Application Manager: Regulatory Quantitative Analysis
Library Number  720000530EN
This brochures describes the TargetLynx Application Manager, an extension of MassLynx Software. TargetLynx addresses regulatory quantitative analysis needs: it automates data acquisition, processing, and reporting. TargetLynx incorporates a wide range of confirmatory checks that allow samples that fall outside user-specified or regulatory thresholds to be easily identified, and provides added confidence when reporting quantitative results.


Exact Mass GC/MS Analysis of Amine Monomers used in CombinatorialLibrary Production
Library Number  720000531EN


A novel dual electrospray ion source interfaced to an orthogonal acceleration-time-of-flight mass spectrometer coupled with liquid chromatography for exact mass measureement of six synthetic polymer additives
Library Number  720000535EN


Data for the calculation of the molecular masses of peptides and proteins for use in mass spectrometry
Library Number  720000536EN


Data for the calculation of the molecular masses of glycopeptides, glycoproteins and oligosaccharides for use in mass spectrometry
Library Number  720000537EN


Amino Acid and Bile Acid Information
Library Number  720000538EN


Acylcarnitine Information
Library Number  720000539EN


The Genetic Code Nominal mass and amino acid changes genetically governed by single base changes in the nucleotide codon
Library Number  720000540EN


A multiplexed liquid chromatography/mass spectrometry system for early candidate profiling in drug discovery
Library Number  720000541EN
Characterization of the physiochemical properties of drug candidates is an important aspect of determining the future potential of new chemical entities. Recent developments in the use of liquid chromatography to correlate specific physiochemical properties in the drug discovery process. By performing several diverse chromatographic separations simultaneously, a more complete profile of the properties of a new chemical entity can be achieved and used to evaluate the potential of the drug. Methods and Instrumentation: Physiochemical characteristics of a variety of pharmaceutical compounds are measured under several different separation conditions simultaneously using four chromatographic systems each with UV diode array detection and a single mass spectrometer. Three basic parameter are measured. Sample hydrophobicity (Chromatographic Hydrophobicity Index, CHI), partitioning coefficient using immobilized artificial membrane columns(KIAM), and affinity to bonded active sites are correlated to retention on HPLC columns. Preliminary Data: Experiments were performed with drug mixtures and reversed phase columns for determination of hydrophobicity measurements in basic, neutral, and acidic mobile phase conditions. Retention times were correlated to give CHI values for compounds. The analysis was done on a multiplexed system simultaneously and the data was correlated through a software program. The data demonstrates the ability to gather disparate compound properties in a multiplexed high speed fashion suitable for prescreening in a drug discovery environment.


Fraction Collector III
Library Number  720000542EN
The Waters Fraction Collector III is the next-generation of Waters successful line of fraction collectors. It is an easy-to-use, stand-alone fraction collector designed for use with HPLC and MS application. Compatible with flow rates as high as 300 mL per minute, the WFC III handles a wide range of adapter racks and related collection vessels.


Metabonomics MS coupled to HPLC shows potential for the screening of rat urine in drug development
Library Number  720000544EN
Metabonomics is a rapidly growing area of scientific research. It is a systems approach for studying in vivo metabolic profiles and can provide information on disease state, toxicity and gene function. In metabonomics the effect of a pharmaceutical candidate on a whole animal or organism is investigated by measuring the changes in endogenous metabolites over a time course following compound adminstration. The analytical data generated in these studies is analyzed by mathematical techniques such as principal component analysis (PCA) to highlight both subtle and gross differences in the samples. This metabonomics approach is now being investigated by large pharmaceutical companies to screen compounds for toxicity, lead compound selection and human disease profiles to name a few. To date the vast majority of work in this field has utilized 1H-NMR as the analytical method of choice. While being very effective, NMR has two significant disadvantages: poor sensitivity and lack of analyte resolution leading to the masking of low abundance analytes by high concentration components. Electrospray LC/MS has become the technique of choice for bioanalysis, both quantitative and qualitative. Here we describe how electrospray LC/MS can be successfully employed in the metabonomic analysis of rat urine derived from a toxicological study.


1525 Binary HPLC Pump
Library Number  720000545EN


PFK reference ions
Library Number  720000546EN


Heptacosa reference ions
Library Number  720000547EN


MaxEnt: An Essential Maximum Entropy Based Tool
Library Number  720000553EN


Monitoring Protein Expression in Haemophilus infuenzae using 2D Semi Preparative Electrophoresis and Mass Spectrometry
Library Number  720000555EN


The Analysis Of Dioxins And Furans Using HRGC-High Resolution MS With The Autospec Ultima NT
Library Number  720000556EN


GCT Mass Spectrometer specifications
Library Number  720000560EN


Trade-In Program for the 996 PDA Detector
Library Number  720000569EN
The Waters 2996 Photodiode Array (PDA) Detector Conversion Program provides you with a conversion kit that includes everything you need to convert your current 996 PDA detector to the latest, state-of-the-art 2996 PDA detector.


Combined Strengths of HPLC and Mass Spectrometry catalog
Library Number  720000570EN


Q-Tof API-US.... Introducing the ultimate tandem mass spectrometer for research in the USA
Library Number  720000571EN


Empower 2 Software: LAC/E-32 specifications
Library Number  720000575EN
This Empower data sheet describes the available configurations of the LAC/E-32 Acquisition Server (Microsoft Windows XP Pro, Windows 2000 Pro and Windows NT Workstation 4.0) plus hardware specifications. Part numbers are included.


Empower 2 Software: Automated custom calculations
Library Number  720000576EN
Empower and Empower 2 Software provide the Custom Calculation Tools necessary for final result calculations without the time, cost or potential errors associated with manual calculations or the use of spreadsheet calcualtions for exported chromatography data files.


Intelligent Speed (IS ™) Columns - Chinese language version
Library Number  720000577CH

In order to address sample throughput concerns of today’s chromatographers Waters has developed new, innovative 20 mm Intelligent Speed (IS) columns that can be run at higher flow rates and lower backpressures without sacrificing resolution.

Historically, to achieve robust separations, scientists used long columns that contained large particles. These configurations produced methods with lengthy analytical run times. To overcome this, Waters’ new highly efficient IS columns use advanced column hardware and packing techniques, thereby allowing older methods to be easily transferred and newer methods developed with shorter run times and lower backpressures. This results in a dramatic reduction in analytical run time, increased sample throughput and overall shorter product development time.

The new IS columns are available in all Waters innovative chemistries including SunFire™, XTerra®, Symmetry®, and Atlantis™. The wide variety of available chemistries, particle sizes and column internal diameters make method development, method transfer and scale-up to preparative chromatography fast and easy.



Intelligent Speed (IS ™) Säulen
Library Number  720000577DE

In order to address sample throughput concerns of today’s chromatographers Waters has developed new, innovative 20 mm Intelligent Speed (IS) columns that can be run at higher flow rates and lower backpressures without sacrificing resolution.

Historically, to achieve robust separations, scientists used long columns that contained large particles. These configurations produced methods with lengthy analytical run times. To overcome this, Waters’ new highly efficient IS columns use advanced column hardware and packing techniques, thereby allowing older methods to be easily transferred and newer methods developed with shorter run times and lower backpressures. This results in a dramatic reduction in analytical run time, increased sample throughput and overall shorter product development time.

The new IS columns are available in all Waters innovative chemistries including SunFire™, XTerra®, Symmetry®, and Atlantis™. The wide variety of available chemistries, particle sizes and column internal diameters make method development, method transfer and scale-up to preparative chromatography fast and easy.



Intelligent Speed (IS ™) Columns
Library Number  720000577EN

In order to address sample throughput concerns of today’s chromatographers Waters has developed new, innovative 20 mm Intelligent Speed (IS) columns that can be run at higher flow rates and lower backpressures without sacrificing resolution.

Historically, to achieve robust separations, scientists used long columns that contained large particles. These configurations produced methods with lengthy analytical run times. To overcome this, Waters’ new highly efficient IS columns use advanced column hardware and packing techniques, thereby allowing older methods to be easily transferred and newer methods developed with shorter run times and lower backpressures. This results in a dramatic reduction in analytical run time, increased sample throughput and overall shorter product development time.

The new IS columns are available in all Waters innovative chemistries including SunFire™, XTerra®, Symmetry®, and Atlantis™. The wide variety of available chemistries, particle sizes and column internal diameters make method development, method transfer and scale-up to preparative chromatography fast and easy.



Columnas Intelligent Speed (IS ™)
Library Number  720000577ES

In order to address sample throughput concerns of today’s chromatographers Waters has developed new, innovative 20 mm Intelligent Speed (IS) columns that can be run at higher flow rates and lower backpressures without sacrificing resolution.

Historically, to achieve robust separations, scientists used long columns that contained large particles. These configurations produced methods with lengthy analytical run times. To overcome this, Waters’ new highly efficient IS columns use advanced column hardware and packing techniques, thereby allowing older methods to be easily transferred and newer methods developed with shorter run times and lower backpressures. This results in a dramatic reduction in analytical run time, increased sample throughput and overall shorter product development time.

The new IS columns are available in all Waters innovative chemistries including SunFire™, XTerra®, Symmetry®, and Atlantis™. The wide variety of available chemistries, particle sizes and column internal diameters make method development, method transfer and scale-up to preparative chromatography fast and easy.



Les colonnes Intelligent Speed , IS ™
Library Number  720000577FR

In order to address sample throughput concerns of today’s chromatographers Waters has developed new, innovative 20 mm Intelligent Speed (IS) columns that can be run at higher flow rates and lower backpressures without sacrificing resolution.

Historically, to achieve robust separations, scientists used long columns that contained large particles. These configurations produced methods with lengthy analytical run times. To overcome this, Waters’ new highly efficient IS columns use advanced column hardware and packing techniques, thereby allowing older methods to be easily transferred and newer methods developed with shorter run times and lower backpressures. This results in a dramatic reduction in analytical run time, increased sample throughput and overall shorter product development time.

The new IS columns are available in all Waters innovative chemistries including SunFire™, XTerra®, Symmetry®, and Atlantis™. The wide variety of available chemistries, particle sizes and column internal diameters make method development, method transfer and scale-up to preparative chromatography fast and easy.



Intelligent Speed (IS ™) Columns - Japanese language
Library Number  720000577JA

In order to address sample throughput concerns of today’s chromatographers Waters has developed new, innovative 20 mm Intelligent Speed (IS) columns that can be run at higher flow rates and lower backpressures without sacrificing resolution.

Historically, to achieve robust separations, scientists used long columns that contained large particles. These configurations produced methods with lengthy analytical run times. To overcome this, Waters’ new highly efficient IS columns use advanced column hardware and packing techniques, thereby allowing older methods to be easily transferred and newer methods developed with shorter run times and lower backpressures. This results in a dramatic reduction in analytical run time, increased sample throughput and overall shorter product development time.

The new IS columns are available in all Waters innovative chemistries including SunFire™, XTerra®, Symmetry®, and Atlantis™. The wide variety of available chemistries, particle sizes and column internal diameters make method development, method transfer and scale-up to preparative chromatography fast and easy.



Intelligent Speed (IS ™) Columns - Korean language
Library Number  720000577KO

In order to address sample throughput concerns of today’s chromatographers Waters has developed new, innovative 20 mm Intelligent Speed (IS) columns that can be run at higher flow rates and lower backpressures without sacrificing resolution.

Historically, to achieve robust separations, scientists used long columns that contained large particles. These configurations produced methods with lengthy analytical run times. To overcome this, Waters’ new highly efficient IS columns use advanced column hardware and packing techniques, thereby allowing older methods to be easily transferred and newer methods developed with shorter run times and lower backpressures. This results in a dramatic reduction in analytical run time, increased sample throughput and overall shorter product development time.

The new IS columns are available in all Waters innovative chemistries including SunFire™, XTerra®, Symmetry®, and Atlantis™. The wide variety of available chemistries, particle sizes and column internal diameters make method development, method transfer and scale-up to preparative chromatography fast and easy.



BioSuite HPLC Columns for Protein and Peptide Separations
Library Number  720000578EN
Waters BioSuite™ HPLC columns for protein and peptide separations contain new high-performance chemistries dedicated to the isolation, analysis, and characterization of biomolecules. Separation offerings include ion-exchange, size exclusion, hydrophobic interaction, and reversed-phase columns and support Waters array of LC and LC/MS systems. Some of the key performance attributes of the BioSuite columns for protein and peptide separations include: * Ion-exchange, size exclusion, hydrophobic interaction and reversed-phase column offerings. * Excellent resolution and recovery of proteins and peptides. * Available in different particle and pore sizes. * Scaleable from analytical to lab scale preparative applications.


NanoEase™, Trapping and Capillary Columns for LC and multidimensional LC/MS Applications
Library Number  720000579EN
The application of LC and LC/MS techniques for the separation and characterization of complex biological compounds is increasing. In addition, use of two-dimensional chromatography prior to mass analysis (i.e., on-line ion-exchange followed by gradient reversed-phase separations) is a promising adjunct to 2 dimensional PAGE for separating difficult samples (e.g., low abundance, hydrophobic, as well as acidic or basic proteins). To assist in these areas of investigation, Waters offers a variety of reagents, chromatography columns, instrumentation, and software to help scientists get answers right on time.


Exact Mass LC/MS/MS Identification Of Drug Metabolites In A Cassette Of Four Microsomal Incubations (Montreux2002)
Library Number  720000581EN
--To provide rapide analysis of drug metabolites in a cassetted sample using exact mass-measured data (<5ppm) for confirmation of predicted and unexpected metabolites at low concentration. --To investigate the clearance of the parent drug and the appearance of its major Phase 1 metabolites over time. --Microsomal incubation at 37 degress Celsicus of 4 pharmaceutical-like compounds sampled at various time intervals over 45 minutes. Subsequent cassetting into groups of 4. --Fast, reversed phase (C18) chromatography and full-spectral TOF-MS, mass- measured by means of an external reference compound infused using a dual electrospray ion source. --Automated exact mass MS/MS experiments on chromatographic peaks of interest. --4 x analytical throughput. --Positive confirmation of metabolite identification. --Determination of rates of metabolism.


EMD 1000 Mass Detector data sheet
Library Number  720000582EN
This 2-page data sheet highlights the Waters EMD 1000, a new mass detector that offers the performance and robustness scientists require for routine mass detection. By adding an EMD 1000 to an Empower or Millennium 4.0-controlled LC/UV system chemists can generate valuable mass information in their own laboratory. This minimizes the need to send out samples for advanced analysis, maximizes the knowledge gained from each sample analysis and increases scientists'' confidence in their analytical results. With the Waters EMD 1000 scientists can: -Confirm suspicions about LC/UV results -Acquire additional sample information for faster and easier decision-making -Easily determine elution order in methods development -Confirm the molecular weight of synthesis products in their own laboratory -Incorporate MS capabilities in a networked, compliant environment


Laboratory Informatics Solutions: MassLynx 4.0 Software
Library Number  720000583EN

With increasingly complex data acquisition capabilities and data processing requirements, it is easy to become overwhelmed when adding or upgrading MS instruments in your laboratory. To maintain and increase your lab''s productivity, you need to simplify your interaction with the MS system, while still retaining the ability to perform advanced experiments.

This brochure details MassLynx 4.0 Software, which improves your ability to manage Waters MS and MS/MS systems with its Sample Centric focus, intuitive operation, and intelligent instrument control. And by combining MassLynx Software with one of its application-specific Application Managers, you gain powerful data processing capabilities to meet your specific analytical needs.

MassLynx Software is part of the Waters Laboratory Informatics suite.



Ionization Capabilities for Waters LC/MS and LC/MS/MS Systems
Library Number  720000584EN
Although LC/MS and LC/MS/MS are incredibly powerful techniques for sample analysis, they are only effective if compounds are ionized and desolvated. Choosing the correct ionization source for mass spectrometers is critically important for successful analyses. To fully leverage MS instrumentation, Waters offers the following ionization capabilities: -Electrospray Ionization (ESI) Probe -Atmospheric Pressure Chemical Ionization (APCI) Probe -IonSABRE APCI Probe -ESCi Multi-Mode Ionization Source* -APPI/APCI Dual Ionization Source -MUX-technology


Alliance Bioseparations Systems
Library Number  720000589EN

This brochure presents an overview of the Alliance Bioseparations Systems. Within the challenges of protein analysis, the Alliance Bioseparations System provides an automated, reproducible alternative to the 2D gel electrophotetic technique. This system is a high-pressure, high resolution HPLC for the fractionation and analysis of complex biomolecule mixtures. Its high pressure also makes the system ideal for the fractionation and analysis of complex biomolecule mixtures.



Empower 2 Software: ApexTrack integration algorithm
Library Number  720000592EN
This technical note provides details about ApexTrack, an integration algorithm that is included with Empower and Empower 2 Software.


Symmetry Columns Applications Notebook
Library Number  720000593EN
The Symmetry applications notebook is a comprehensive collection of over 170 applications in the areas of pharmaceutical, biopharmaceutical; environmental; clinical; Industrial; forensics; proteomics and life sciences. Many of the applications also provide sample preparation procedures for different sample matrices including serum, plasma, blood, urine; water, soil and food using Oasis SPE sorbents. Symmetry columns have set the industry standard in terms of reproducibility, versatility, and performance offering our customers a powerful tool for almost any method development challenge.


Quattro Premier Mass Spectrometer
Library Number  720000594EN
Specialized quantitative applications, including ADME screening, bioanalysis, clinical analysis, as well as food safety and environmental monitoring, require high sensitivity, high performance LC/MS/MS instrumentation. Compliance with stringent regulatory guidelines may also be necessary with these applications. Now scientists can achieve high performance and low detection limits in a compact, easy-to-use system that includes the Waters Quattro Premier Tandem Quadrupole Mass Spectrometer, featuring T-Wave (Travelling Wave) technology. To ensure high quality, secure data--method development to high throughput quantitative analyses--MassLynx 4.0 Software and its dedicated Application Managers make operating the Waters LC/MS/MS Systems easier than ever before.


Industrial Solutions: Environmental, Food, Agrochemicals, Natural Products
Library Number  720000596EN
In this brochure, we demonstrate the range of LC, mass spectrometry and related analysis techniques that Waters brings to environmental, food, agrochemical and natural products industries. We offer a complete range of LC/MS and LC/MS/MS system solutions that will product the information you need.


PrepLC 150 mL and 300 mL system specifications
Library Number  720000598EN
Specification sheet for PrepLC 150 mL and 300 mL systems.


Alliance 2796 XE and XC Bioseparations Module specifications
Library Number  720000599EN
The Alliance Bioseparations System is a high-pressure, high-resolution HPLC system for the fractionation and analysis of complex bimolecule mixtures. The heart of the Alliance Bioseparations System is the Waters 2796 Bioseparations Module. Designed for robust operation under the harsh salt and pH conditions typical of bioseparations, it features a titanium and PEEK flowpath. The system''s high-pressure capability also makes it ideal for protein purification, peptide mapping and nucleic acid analysis.


Waters System Solutions: Metabolic Profiling
Library Number  720000602EN

The keys to success in metabolic profiling: Rapid analyte detection. High sensitivity and resolution. Robust data processing. With Waters system solutions, you get all the answers you need in metabolite identification, metabonomics and metabolomics research.

The understanding of biotransformation for new chemical entities (NCE) is a critical step in the drug discovery process. Once a compound reaches the development stage, metabolite identification becomes a regulated process—when it is of the utmost importance to detect and identify all circulating metabolites of a candidate drug.

In tandem, metabonomics studies are also fast becoming a means to dramatically accelerate the development of new medicines. The ability to compare and contrast large sample groups provides insight into the biochemical changes that occur when a biological system is exposed to an NCE. Metabonomics provides a rapid and robust method for detecting these changes, improves researchers’ understanding of toxicity, and allows them to monitor efficacy.

Waters addresses challenges for pharmaceutical, healthcare and agrochemical industries with an unrivalled suite of system solutions. From our innovative Ultra Performance LC (UPLC) technology and our high-resolution exact mass Premier family of mass spectrometers (LCT Premier XE, Q-Tof Premier, GCT Premier), to our specialized MassLynx Software Application Manager for multivariate analysis and database searches, Waters offers the integrated tools that will give you complete confidence in these challenging fields.



Metabonomics MS System, with UPLC and MarkerLynx Application Manager (Japanese)
Library Number  720000602JA

The emerging fields of metabonomics and metabolomics hold enormous potential for the pharmaceutical, healthcare, and agrochemical industries. Metabonomics uses advanced analytical techniques with statistical data analysis to rapidly identify up- or down-regulated endogenous metabolites and biomarkers in various biofluids and plant extracts as a result of a disease state, toxicity, genetic modification, or environmental factors.

The Waters Metabonomics MS System is specifically designed to address the rigorous requirements of this groundbreaking application. Our total-system solution provides the necessary robustness, accuracy, sensitivity, data processing, and support needs for metabonomics work. The Waters Metabonomics MS System integrates the Waters ACQUITY Ultra Performance LC system with the Micromass LCT Premier mass spectrometer to produce accurate, high-resolution analyses using MassLynx Software and its unique MarkerLynx Application Manager.



Empower 2 Software: Chemical structures option
Library Number  720000603EN
With this Empower 2 Software option, you can display chemical structures on your chromatograms and spectra, as well as print structural information on reports. It also enables effective searching for structural information.


Alliance HPLC System Accessories Product Solution
Library Number  720000604EN
This six-page product solution supports the Alliance HPLC Systems and includes information on the following: GPC Accessories Kit, Bottle Tray Kit, Column Pre-Heater Tubing, Column Heater and Column Heater/Cooler, Automated Switching Valves, Sample Heater/Cooler, and the Post Column Reaction System.


A Novel Approach for Mixed Mycotoxin Analysis
Library Number  720000605EN


Productos Oasis® para la extracción de muestras
Library Number  720000606ES


Oasis Applications Notebook
Library Number  720000609EN
    The new "Oasis Applications Notebook" is a comprehensive collection of applications that encompasses the following 3 previous Oasis Application Notebooks:
  • Waters Oasis Sample Extraction Products Environmental & Agrochemical Applications Notebook [Literature Code 720000421EN]
  • Waters Oasis Sample Extraction Products Forensic Applications Notebook [Literature Code 720000252EN)]
  • Waters Oasis Sample Extraction Products Pharmaceutical Applications Notebook [Literature Code 720000245EN]
    In addition to over 150 applications covering the Pharmaceutical, Environmental, Agrochemical and Forensic Sciences, this notebook contains:
  • Oasis HLB product and generic and optimized methodology
  • Oasis MAX product and generic and optimized methodology
  • Oasis MCX product and generic and optimized methodology
  • Introduction to forensics applications including SAMSHA-5 drugs of abuse
  • Oasis glass cartridge instruction sheet
  • Choosing the correct procedure for EPA (SW-846)
  • Suggested methods for alternative matrices such as tissue homogenates, whole blood, natural products, solid phase synthesis, and catalytic enzyme assays
  • Ordering infromation and part numbers for Oasis products and supplies
  • References to technical presentations and journal articles using Oasis Sample preparation products


Alliance GPC/V 2000 Series Connections Enhancement Program
Library Number  720000610EN
The Alliance GPC 2000 Connections Enhancement Program data sheet provides current Alliance GPC/V 2000 owners with options for enhancing their instruments. Benefits of this program include: -Improved accuracy of results resulting from better baseline signal -Faster stabilization of column compartment temperature -More stable RI and viscometer detector signal -Extended vial holder life -Greater storage space for data files -Easier and faster data backup


Intelligent Data Directed Analysis (DDA)
Library Number  720000611EN

Data Directed Analysis (DDA) enables intelligent MS and MS/MS acquisitions to be performed automatically on multiple co-eluting components. DDA allows you to make intelligent decisions about which ions to select for MS/MS using the inherent high resolution, exact mass measurement capability and full mass range sensitivity of the series of Q-Tof Mass Spectrometers.

With DDA, scientists are able to:

  • Extract the maximum amount of information from complex samples automatically
  • Reduce the analysis time and sample consumption that multiple injections necessitate
  • Increase the specificity of detection for targeted analyses
  • Improve the quality of MS/MS data acquired automatically from low abundance species
  • Focus only on components of interest for targeted MS/MS analyses


Hydrophilic Interaction Chromatography for Enhanced ESI-MS Sensitivity and Retention of Polar Basic Analytes
Library Number  720000613EN
New AtlantisTM HILIC Silica columns retain and separate very polar, water-soluble basic organic compounds using the high organic mobile phases associated with hydrophilic interaction chromatography (HILIC). The highly volatile organic mobile phases used in HILIC provide increased electrospray ionization-mass spectrometry (ESI-MS) sensitivity and complementary selectivity as compared to reversed-phase (RP) chromatography.


Waters Corporate Capabilities-German version
Library Number  720000616DE


Waters Corporate Capabilities-English version
Library Number  720000616EN


Waters Corporate Capabilities-Spanish version
Library Number  720000616ES


Waters Corporate Capabilities-French version
Library Number  720000616FR


Waters Corporate Capabilities-Italian version
Library Number  720000616IT


Waters Corporate Capabilities-Japanese version
Library Number  720000616JA


Waters Corporate Capabilities-Korean version
Library Number  720000616KO


Waters Corporate Capabilities-Simplified Chinese version
Library Number  720000616ZH


EMD 1000 specifications
Library Number  720000618EN
Waters EMD 1000, a single quadrupole, benchtop mass spectrometric detector that runs in a Waters Empower or Millennium®32 4.0 Software environment, is the ideal solution for any chromatography laboratory planning to enhance their qualitative analytical capability. Whether it is peak tracking in methods development, peak identification with impurity analysis, or peak confirmation in high throughput analysis, the EMD 1000 has the capabilities chemists need to improve confidence in their results.


1500 series HPLC pump specifications
Library Number  720000619EN
Specifcations for the 1500 series of HPLC pumps


Breeze HPLC System Software specifications
Library Number  720000620EN
Specifications describing hardware requirements for Breeze software plus which Waters instruments the software controls.


Metabonomics and the Application of LC/MS to the Analysis of Rat Urine from a 90-Day Safety Assessment Study Applications Note
Library Number  720000622EN
An optimized Waters exact mass LC/MS System with a dedicated MassLynx 4.0 Software Application Manager (MarkerLynx Application Manager), has been developed to facilitate the rapid metabonomic analysis of biological fluids. This system is of particular utility in the pharmaceutical industry for the analysis of clinical trial or safety assessment samples, typically urine or plasma. The system and Applications Manager provide a complete solution to facilitate the collection and statistical analysis of bioanalytical data. By employing exact mass and MS/MS analysis, the facile identification of putative endogenous biomarkers is accomplished. This application note shows the use of the Waters Metabonomics MS System with the MarkerLynx Application Manager for the analysis of samples resulting from a 90-day rat safety tolerability study.


A Metabolomic Approach to Analyzing Plant Flavonoids Using Constant Neutral Loss Acquisitions
Library Number  720000623EN


A Metabonomics Approach to the Study of Rat Urine After Dosing with the Hepatotoxin Hydrazine
Library Number  720000624EN


A Metabonomics Approach to Determining Strain, Gender and Diurnal Variations in Mouse Urine by LC/MS Applications Note
Library Number  720000625EN
Metabonomics is defined as a systems approach to investigating the metabolic consequences of (patho) physiological or genetic modification in a multivariate and dynamic manner (1). Furthermore, it is a rapidly emerging science that allows the natural clustering of sample groups to be highlighted after analysis of biofluids (e.g. urine and plasma). In the past, these clustering variations have been elucidated by sample analysis via 1H-NMR and GC/MS. Recently, an LC/MS alternative to the aforementioned techniques has been developed and is readily accomplished by using a Waters exact mass LC/MS system with a dedicated MassLynx 4.0 Applications Manager to allow the seamless acquisition and analysis of metabonomics data.


Determination of Tobramycin in Human Serum Using Liquid Chromatography Tandem MS and Comparison with a Fluorescence Polarization Assay
Library Number  720000626EN


A Comparison of 1H-NMR and LC/MS (TOF) for a Metabonomics Evaluation of Rat Urine from Toxicological Study
Library Number  720000630EN


Time-of-Flight Mass Spectrometry for the Specific Identification of Low Level Metabolites
Library Number  720000631EN


A Novel Method for Desalting and Purification of Peptide Samples Prior to NanoSpray-MS
Library Number  720000633EN


Travelling Wave Ion Propulsion in Collision Cells
Library Number  720000635EN


Qualitative and Quantitative Analysis of Small Molecules by MALDI Mass Spectrometry Through Charge Derivatization
Library Number  720000636EN


Desorption/Ionization on Silicon Mass Spectrometry (DIOS/MS) of Small Molecules and Peptides: Sample Handling, Preparation and Storage Effects on Performance
Library Number  720000637EN


Strategies for Identifying Proteins in Complex Mixtures by Electrospray Mass Spectrometry
Library Number  720000640EN


Accelerated Endopeptidase Digestion of Proteins Employing an HPLC and MS Friendly Surfactant
Library Number  720000641EN


Comparison of Peak Parking Versus Automated Fraction Analysis of a Complex Protein Mixture
Library Number  720000642EN


A Multidimensional LC/ESI-TOF MS Prefractionation Approach for the Analysis of Intact Proteins in Complex Proteomes
Library Number  720000643EN


Use of Staggered Chromatography for High Throughput Bioanalysis
Library Number  720000644EN


The Use of Parallel LC/MS/MS with Automated Optimization to Increase Throughput for the Quantification of Incubated Drug Candidate Samples
Library Number  720000645EN


Charge State Discrimination by Means of Ion Storage at Intermediate Pressures
Library Number  720000647EN


An LC/MS Orthogonal TOF (Time-Of-Flight) Mass Spectrometer with Increased Transmission, Resolution and Dynamic Range
Library Number  720000648EN


Analysis of Capillary Reversed-Phase HPLC Separations of 1-D Gel Digests by MALDI MS/MS
Library Number  720000649EN


Comparison of the Desalting Methods for MALDI TOF MS Analysis of Oligonucleotides
Library Number  720000650EN


High Mass Accuracy Measurements in W-Optics using an Orthogonal Hybrid Quadrupole Time-Of-Flight Mass Spectrometer for in vitro Metabolism Studies
Library Number  720000652EN


Importance of Chromatographic Efficiency in Analysis of Complex Matrices by LC/MS
Library Number  720000654EN


Mass-Directed Purification of Long-Chain Synthetic Oligonucleotides at µmole Scale
Library Number  720000655EN


Analysis of Polylactide Glycolide by Coupled GPC/MALDI-MS
Library Number  720000656EN


Complete Tryptic Digestion of Membrane Protein Bacteriorhodopsin
Library Number  720000658EN


Glycosylation Analysis of Recombinant E2 BVDV Protein from a Semi-Purified Fraction Using a Waters Micromass CapLC Q-Tof
Library Number  720000664EN


Quantification of Fentanyl and Norfentanyl in Urine by LC/MS-ESI with Multi-Ion Confirmation
Library Number  720000666EN


Identification of Novel Biomarkers of Genetic State in Mice by LC/MS and Metabonomics
Library Number  720000667EN


A Novel MS-Based Metabonomic Approach to the Determination of Biomarkers of Drug Toxicity
Library Number  720000668EN


An Interactive Physicochemical Property Profiling Software for Early Candidate Analysis in Drug Discovery
Library Number  720000669EN


A Fully Automatic Multi-Analyte Quantification Protocol for Carbamates - A Comparison of LC/MS and LC/MS/MS
Library Number  720000672EN


Improvements in Mass Measurement Accuracy and Reporting Over Increased Dynamic Range Using Orthogonal TOF Mass Spectrometers
Library Number  720000673EN


Charge State Separation by Linked Scanning a Mass Filter with Mobility Separator
Library Number  720000677EN


A Rapid LC/MS Method for the High Throughput Quality Control of Long Oligonucleotides
Library Number  720000678EN


The Implication of Column Peak Capacity and Selectivity on the Multi-dimensional LC/MS Analysis of Complex Peptide Mixtures
Library Number  720000680EN


Waters Customer Satisfaction Annual Report
Library Number  720000683EN
The Waters Customer Satisfaction Report provides an overview and rating of our Waters Connections Customer Success Program. The report was conducted by Omega Management Group Corp., an independent auditing group that surveyed more than 3,000 Waters customers worldwide to benchmark customers' perceptions and satisfaction with Waters products and services. The report covers several areas, including Service Process, Field Service Engineering, Customer Loyalty and Overall Satisfaction.


2767 Sample Manager
Library Number  720000685EN
The 2767 Sample Manager is a high-capacity sample processing system, controlled by MassLynx software.


A Multi-Residue LC/MS/MS Method For The Determination Of 81 Pesticide Residues In Fruit and Vegetables: PART 1, Method Overview
Library Number  720000686EN


Optimization of a Database for Rapid Identification of Intact Bacterial Cells of Escherichia Coli by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Library Number  720000689EN


The Confirmation of the Presence of Incurred Pesticide Residues Detected using a Multi-Residue Surveillance Method to Screen for 81 Target Analytes
Library Number  720000692EN


The Advantages of Multiple Reaction Monitoring (MRM) Over Single Ion Recording (SIR) for the Analysis of 81 Pesticide Residues in Fruit and Vegetables
Library Number  720000693EN


Compound Purification Workflow Management and Optimization
Library Number  720000696EN
Traditionally, drug discovery laboratories have screened large libraries with mininal to no purity requirements. Today, laboratories screen libraries that are smaller and more focused with specific purity limits, typically 85% or greater. This places a greater burden on the overall purification process. Efficiently managing this burden requires purification strategies that dovetail into the overall synthesis-to-screen process. This poster illustrates how a compound library is taken through a purification process, using the Waters AutoPurify Software.


600E Multisolvent Delivery System
Library Number  720000699EN
The 600E single pump gradient system is a pump that provides compositionally accurate and precise eluent blends at all flow rates and backpressures, even at compositional extremes. AutoBlend capability automatically blends up to four eluents in accurate proportions, runs any sequence of isocratic combinations, binary, tertiary and quaternary gradients for automated methods development, column cleanup, system flushing and sample prep.


PrepLC and DeltPrep Systems
Library Number  720000700EN
Four-page, four-color data sheet that describes the new series of Waters PrepLC and DeltaPrep systems that provide extraordinary performance and convenience for benchtop purification of microgram to multi-gram sample loads.


Empower 2 Software: email capabilities
Library Number  720000701EN
Empower 2 Software offers scientists the flexibility to efficiently transfer completed HPLC or GC information electronically.


Empower 2 Software: Creating custom drop-down lists
Library Number  720000702EN
Empower 2 Software, with its integrated relational database, makes it easy to create a drop-down list that can be used to assign the analytical column (or location, sample matrix, client name, etc) used for each sample.


Simultaneous Analysis of Risperidone, 9-Hydroxyrisperidone and Haloperidol in Plasma
Library Number  720000703EN


Evaluation of Improvements in Mass Accuracy of Q-Tof Ultima API for the Rapid and Automated Screening of Compound Libraries
Library Number  720000704EN


A Method for the Determination of Nitrofuran Veterinary Drug Residues by LC/MS/MS
Library Number  720000705EN


Exact Mass MS/MS of Ibuprofen Metabolites Using a Hybrid Quadrupole-Orthogonal Time-of-Flight Mass Spectrometer Equipped with a LockSpray Source
Library Number  720000706EN


Making compliance work for you
Library Number  720000707EN
This four page brochure is based on the interview with Dr. Bob McDowall that first appeared as one of the Time Magazine cover wraps. In the interview Dr. McDowall talks about the pressures analytical laboratories face to increase productivity while complying with stringent documentation regulations. Dr. McDowall feels that lab managers who objectively pinpoint bottlenecks, design a more efficient workflow and invest in scalable, flexible, compliant-ready software, such as Empower or MassLynx, can not only overcome tough compliance issues, but also increase their lab''s productivity.


Exact Mass Measurement
Library Number  720000709EN

For the identification and characterization of compounds, exact mass measurement in MS can be used to gain high specificity for identifying nominally isobaric components. Exact mass measurement in MS/MS gives scientists the added power to more confidently identify compounds and characterize structural fragments, where nominal mass data may be inconclusive.

The high resolution capability of Waters orthogonal time-of -flight (oa-ToF) mass spectrometers enhance the analysis of compounds from complex matrices by minimizing co-eluting interferences, resolving components of interest even at low abundance. With Waters oa-ToF systems and LockSpray technology scientists can achieve automated, routine exact mass measurement in MS and MS/MS, enabling maximum confidence in results.



2777 Sample Manager specifications
Library Number  720000716EN


Fraction Collector III specifications
Library Number  720000717EN


Continuing Development of the AutoSpec Ultima NT
Library Number  720000718EN


Quattro micro GC
Library Number  720000719EN


Analysis Of Brominated Flame Retardants Using The Autospec Ultima NT
Library Number  720000720EN


2996 Photodiode Array Detector: Optimization for Intelligent Speed (IS™) Columns
Library Number  720000722EN
The 2996 PDA Detector: Optimization for IS™ Columns Technical Note looks at the effects of sampling rate on reproducibility, peak shape, and resolution, along with the effects of digital filtering on signal to noise, resolution and peak capacity. Related Technical Note: Alliance® 2695 Separations Module: Optimization and Performance with 4.6 mm i.d. Intelligent Speed (IS) Columns (720000723EN).


Alliance 2695 Separations Module: Optimization and Performance with 4.6 mm i.d. Intelligent Speed (IS) Columns
Library Number  720000723EN
Focus on Alliance® 2695 Separations Module for use with IS columns. A series of fast gradients were run at different flow rates to determine the effect on the reproducibility of retention times and peak areas. Peak capacities for the columns at the different flow rates were also calculated. Additional information on Waters instruments with IS columns can be found in Technical Note 720000722EN titled: Waters 2996 Photodiode Array Detector: Optimization for Intelligent Speed Columns.


A Fully Automated Software Strategy for De Novo Sequencing of Whole Q-TOF Electrospray LC/MS/MS Datasets
Library Number  720000724EN
This application note describes the use of a Bayesian probability based de novo sequencing algorithm automatically applied to an entire LC/MS/MS dataset. The resultant sequences are compared to the results obtained from a databank search using the same dataset.


A Rapid On-Line Assay for the Clinical Diagnosis of Amyloidogenic Transthyretin
Library Number  720000731EN
Familial transthyretin amyloidosis is an inherited systemic disease in which protein deposits ultimately lead to organ failure(s) and death. Familial transthyretin amyloidosis is associated with genetic variants of transthyretin in which single amino acid substitutions have been found in the primary structure. Transthyretin is a plasma transport protein that exists as a monomer of mass 13761 amu containing 127 amino acids. It circulates as a tetramer in plasma and has unique binding sites for both thyroxine and retinol binding protein. One recent count indicated 84 genetic variants, the vast majority being amyloidogenic1. Screening for known variants and identification of unknown variants poses a unique set of problems. In response to some of these issues, we developed an on-line assay for transthyretin genetic variants that utilizes an immunoaffinity column to purify transthyretin directly from 20 µL of serum. The immunopurified transthyretin is desalted on a reversed phase trap and eluted into the electrospray source of a mass spectrometer for analysis. Transformed spectra of the resulting multiply charged spectra clearly indicate the presence or absence of transthyretin genetic variants. On all analyses to date, perfect correlation has been found between actual DNA sequence analysis and mass spectral results. The results are obtained in less than twenty minutes and are easily automated providing a rapid assay for screening for common genetic variants.


Structural Analysis of the Amyloidogenic Immunoglobulin Light Chains Directly from Serum by Online Immunoaffinity Isolation
Library Number  720000732EN
Primary systemic amyloidosis (AL) is characterized by the overproduction of immunoglobulin light chain proteins by a monoclonal, terminally differentiated Blymphocyte, or plasma cell clone. The free immunoglobulin light chain gets deposited in an abnormal conformation as amyloid in a variety of organs in the body. Current diagnostic methods include staining of tissue biopsies or immunodetection of cytoplasmic light chains in bone marrow biopsies. These methods give no information on the morphology of the light chains, however. In an effort to elucidate the structural basis of the immunoglobulin light chain that forms amyloid, in this disease, we developed an on-line assay for kappa and lambda light chains utilizing an immunoaffinity cartridge specific for each protein''s constant region. The immunoaffinity cartridge effluent is coupled to an electrospray ionization-mass spectrometer for final analysis.


Industrial Solutions: Food Safety
Library Number  720000733EN
Testing of food stuffs for a variety of contaminants, including the residues of veterinary drugs and pesticides, is a requirement for exported, imported and domestic produce. The allowed levels of contaminant compounds are regulated by government bodies in many countries and require the ability to detect compounds at trace levels. Waters System for Food Safety is complete with the instruments, software, chemistries, methods and services needed to accurately analyze food samples.


2420 Evaporative Light Scattering Detector: Analysis of Polyethylene Glycol
Library Number  720000735EN


Empower 2 Software: Controlling the Agilent HS7694 headspace autosampler
Library Number  720000736EN
This data sheet describes the Empower 2 Software option that gives users control of the Agilent model G1290B headspace analyzer, a.k.a. the HS7694.


Intelligent Speed (IS ™) Columns Application Notebook
Library Number  720000737EN
Intelligent Speed (IS™) columns from Waters give today’s chemist more than the raw speed they need for high-throughput HPLC. • Increasing throughput and productivity – more results in less time • Reducing the overall cost per analysis • Shortening new product development timelines Only IS™ columns incorporate the knowledge and intelligence necessary for today’s speed requirements while maintaining peak efficiency through optimized column hardware design and packing technology. IS™ columns are available in all Waters innovative chemistries (XTerra®, Symmetry®, SymmetryShield™ and Atlantis™) with a wide variety of stationary phases, particle sizes and internal diameters.


Use of NanoLockSpray Electrospray Interface for Exact Mass Proteomics Studies
Library Number  720000738EN
This application note describes the implementation of a dual sprayer NanoLockSpray source on the Waters Q-Tof micro mass spectrometer. This NanoLockSpray source consists of a dual sprayer arrangement; one for the nanolitre/min flow rate from the analyte, while the second is for the reference compound. This facilitates routine exact mass measurement for nano scale LC/MS and MS/MS studies.


Dioxin and Furan Analysis in Animal Feedingstuffs to EU Limits Using the Waters AutoSpec Ultima NT
Library Number  720000739EN


Improved Sample Preparation Techniques for MALDI-TOF Mass Spectrometry Using the MassPREP PROtarget Plate
Library Number  720000740EN
MALDI-TOF MS is a widely used and highly specific technique for the analysis of proteins and peptides. MALDI is a robust technique that generally has a high tolerance of salts and contaminants, however removal of these impurities prior to analysis significantly improves the data quality, the number of peptides observed and can vastly improve the confidence with which proteins are identified. This application note describes a new method for sample preparation that involves the use of a new MALDI target plate, the Waters MassPREP PROtarget Plate.


The Use of Q-Tof for the Characterization of an N-Linked Glycosylation Site in Native Cauliflower Xyloglucan Endotrans Glycosylase
Library Number  720000741EN
Proteins frequently possess post-translational modifications, thus resulting in an increase in protein mass, which often cannot be predicted from the gene sequence. Common post-translational modifications are phosphorylation, sulfation, acetylation, and glycosylation. The combination of capillary liquid chromatography, electrospray ionisation, and Time-of-Flight (TOF) mass spectrometry provides a powerful approach for the analysis of these structural modifications.


Separation and Purification of Highly Polar Pharmaceutical Compounds on a RPLC Column at Prep Scale: Are You Thinking about Atlantis™ dC18
Library Number  720000742EN
Atlantis™ dC18 columns are a fully LC/MS compatible line of reversed-phase columns designed for retaining and separating both highly polar and non-polar compounds. This new silica based packing material has excellent stability in acidic mobile phases and is fully compatible with 100% aqueous mobile phases. With Atlantis™ dC18 columns, direct scale-up from analytical to preparative dimensions is simple. To demonstrate the utility of Atlantis™ dC18 columns, we separated and purified three mixtures of polar compounds. Our results indicate that Atlantis™ dC18 preparative columns provide excellent efficiency, high mass loading, and ease of scale-up.


SEC–MS Analysis of Aggregates in Protein Mixtures
Library Number  720000743EN
Size exclusion chromatography (SEC) coupled with mass spectrometry was used to study heat-induced aggregation in protein mixtures.


Fast Separations: Higher Throughput and Reduced Costs
Library Number  720000744EN
Today''s chemists are being asked to increase productivity and reduce their laboratory costs. In the area of high-performance liquid chromatography (HPLC), one way of achieving these requests is to reduce the overall runtime of a separation. We have developed new columns in 20 mm lengths packed with a variey of stationary phases that offer excellent peak shapes, reproducibility, and fast separations for high sample throughput. We have used these columns to scale separations from a 150 mm length to a 20 mm lenth column.


Analysis of various cyanobacterial toxins by LC-MS
Library Number  720000745EN


MassPREP PROtarget Plates with ActiveWell Technology
Library Number  720000747EN
Sample preparation for MALDI mass spectrometry has taken a giant step forward. Now scientists can prepare samples faster and easier than ever before and significantly improve the sensitivity of their MS analyses. By incorporating the innovative ActiveWell Sample Preparation Plate Technology, Waters® MassPREP PROtarget Plates enable high-volume sample loading and on-target cleanup for simplified sample preparation and improved detection limits for lower abundance proteins.


Waters Quattro micro GC specifications
Library Number  720000748EN
The Waters Quattro micro™ GC is a tandem quadrupole mass spectrometer equipped with Electron Impact (EI) and Chemical Ionization (CI+/CI-) sources.


The Use of Parallel LC/MS /MS with Automated Optimization to Increase Throughput for the Quantification of Incubated Drug Candidate Samples
Library Number  720000749EN
This application note will demonstrate the use of the Waters® Micromass® Quattro micro with MUX-technology and QuanOptimize together with multi-pump control (four Waters 1525 µ binary pumps) in the analysis of incubated samples in order to increase throughput for quantitative ADME studies in drug discovery. Here we present a multiplexed electrospray ionization source interfaced to a tandem quadrupole mass spectrometer. The system is set up in such a way as to automatically generate compound optimization and integration parameters using QuanOptimize. This resulted in the generation of intrinsic clearance plots for 76 drug candidates.


600E Multisolvent Delivery System specifications
Library Number  720000751EN
Waters 600E Multisolvent Delivery System offers no-compromise high performance in a true single pump design.


AMDS Method Transfer: Instrument-To-Instrument Dwell Volume Differences
Library Number  720000752EN
Traditional manual method development and transfer can be a labor-intensive, time-consuming, and often imprecise process. The process becomes even slower and more frustrating when the method that needs to be transferred requires modification in the end user''s lab. The Waters Automated Method Development System (AMDS) is a tool that can increase efficiency and throughput to streamline these issues.


Peptide Charts
Library Number  720000755EN
These peptide charts list data for the calculation of the molecular masses of peptides and proteins for use in mass spectrometry.


LC/MS Analysis of Vitamin B12
Library Number  720000758EN
Vitamin B12 is a water-soluble vitamin that has important physiological function in the human body. In this application note, we describe a simple LC/MS method for the analysis of Vitamin B12 standard.


A Single Injection Screening Method for Tetra-Octa Chlorinated PCDD/FS in Fish and Flyash Matrices Using GC-Triple Quadrupole MS/MS
Library Number  720000759EN


Analysis of Complex Protein Digest Samples by Off-Line Strong Cation Exchange Chromatography in Combination with LC/MS/MS on a Hybrid Quadrupole Orthogonal Acceleration Time-Of-Flight (Q-Tof) Mass Spectrometer
Library Number  720000760EN
Advances in both LC and MS instrumentation have allowed the analysis of protein complexes which have not been separated on a two-dimensional gel. These experiments involve separation of a complex digest mixture by nanoscale liquid chromatography connected to an instrument capable of data directed switching between the MS and MS/MS modes. Protein identification is then achieved via databank searching of the ESI/MS/MS spectra, providing qualitative information on the proteins that are present. Hundreds of MS/MS spectra can be acquired in a fully automated fashion, resulting in the identification of significant numbers of proteins, including low copy number proteins, from a single LC/MS/MS experiment.


Increased Sequence Coverage by Peptide Mass Fingerprinting using MALDI in Combination with N-Terminal Modification of Tryptic Peptides
Library Number  720000761EN
Peptide mass fingerprinting (PMF) is a widely used MALDI TOF MS technique for the identification of proteins. PMF relies on the comparison of experimentally obtained peptide masses from enzymatically digested proteins with theoretical peptide masses, obtained through the in silico digestion of proteins contained within protein or translated nucleotide databanks. The most widely used enzyme is trypsin due to its availability in a pure form and compatibility with mass spectrometry.


New MS Compatible Silver Staining/De-Staining and Sample Cleanup/Concentration Techniques for the Identification of Low Abundant Proteins in 2-D Gel Spots by MALDI Mass Spectrometry
Library Number  720000762EN
Identification and characterization of low abundance proteins separated by 2D gel electrophoresis is complicated by two important factors; the use of suitable staining techniques for the visualization of the proteins on the gel and the need for sample desalting and concentration before analysis by mass spectrometry. Current silver staining protocols only allow for short development times which can lead to problems with background staining and hence problems in discerning lower abundance spots from the background. Presented in this poster is a new silver staining kit based on the method published by Sinha and co-workers (ref 1) which reduces the amount of sample handling and allows for increased development times. This reduces the amount of background staining while retaining the excellent sensitivity and mass spectrometry compatibility compared to current silver staining protocols. Once extracted, sample cleanup and preconcentration is often necessary before analysis by mass spectrometry. Techniques such as microcolumn cleanup involve intensive manual intervention and the possibility of sample loss within the column material itself. However, a new target technology recently presented (ref 2) allows for on target sample concentration and cleanup that reduces sample losses and is particularly amenable to automation. Here we show the use of this technology in the identification of low abundance silver stained gel spots not readily identifiable using standard MALDI plate technology.


Exact Mass LC/MS Used to Determine the Elemental Compositions of a Family of Bromo-Benzyl Alcohol Sulphates from Polysiphonia Lanosa and Gigartina Stellata
Library Number  720000763EN
The marine environment continues to be a source for natural products discovery. The activities of natural marine products can have properties of pharmacological interest, for example, cytotoxicity against tumoral cultured cells, antimicrobial activity and antiviral activity. In addition, anti-feedent activity and insecticidal activity of ecological or agronomical significance has been observed. Algae are known to produce a wide range of compounds[1] that feature novel structures and often prove to be active in biological systems. However, such species found around the British coasts have been largely ignored. During this study, several algae species were investigated, producing two of particular interest. The first is Polysiphonia lanosa, a filamentous, epiphytic red algae collected from Broughty Ferry on the estuary of the River Tay in Scotland, found growing on its host Ascophyllum nodosum. The second is Gigartina stellata, also a red algae, collected from Arbroath on the east coast of Scotland. After collection, the samples underwent a series of solvent extraction and partitioning steps to yield hexane, methanol, dichloromethane and water soluble fractions[2]. Orthogonal acceleration time-of-flight mass spectrometry (oa-TOF-MS), combined with HPLC, proved to be a powerful analytical tool because of its acquisition speed, available mass range, and ion collection efficiency. Within many laboratories the high-duty cycle of TOF is used for qualitative studies, generating full spectra at high mass accuracy (<5 ppm) and providing an extra degree of information that aids in the interpretation of data. Here, fractions were analyzed in 1 mg portions by exact mass LC/MS. The crude extracts generated an overwhelming number of compounds; further work was targeted towards the halogenated compounds found in the water fractions alone.


Exact Mass Measurement: A Powerful Tool in Identification and Confirmation
Library Number  720000764EN
The ability to obtain exact mass measurement is a powerful tool in the identification and confirmation of compounds. It has long been recognized that if an ion can be measured with sufficient accuracy it may be possible to infer a unique elemental composition. Historically, exact mass measurement has been carried out using magnetic sector mass spectrometers, which tend to be large, expensive and require a highly trained operator to deliver good data. This has lead to the perception that exact mass measurement is difficult to achieve. The introduction of orthogonal acceleration-time of flight (oa-TOF) mass spectrometry has greatly simplified exact mass measurement and provided more affordable and compact benchtop instrumentation. Many scientists given the choice of exact mass or MS/MS capabilities would choose MS/MS without appreciating what exact mass can offer. This document gives an overview of exact mass measurement and the benefits of routine application in both MS and MS/MS modes.


Evaluation and Optimization of Reverse Phase Column Material for the Analyses of Complex Tryptic Peptide Mixtures by LC/MS and LC/MS/MS
Library Number  720000765EN
Electrospray mass spectrometry coupled to nanobore reverse phase chromatography has rapidly become the chosen method for the separation and characterization of enzymatically digested protein samples. A key component in the MS analysis is the complexity of the sample that elutes into the mass spectrometer, from the HPLC column, at any given moment in time. This can have a profound influence on the number of peptides and hence proteins identified, and also the dynamic range of the identified components. Therefore, the peak capacity of the chromatographic system is often an important attribute. Additional chromatographic attributes such as retention time reproducibility and injection methods can have profound effect on the results, especially if relative quantification is desired. In this poster we investigate different stationary phases for peptide mapping and in particular we will focus on how to improve chromatographic separations over those methods currently in use. Data will be presented showing the improved peptide recovery, particularly of small, hydrophilic peptides from a protein digest, resulting in an increased level of protein coverage.


A Rapid Method for the Determination of Chloramphenicol Residues in Black Tiger Shrimp
Library Number  720000767EN
A Rapid Method for the Determination of Chloramphenicol Residues in Black Tiger Shrimp describes an extraction and LC/MS/MS method for the quanification and determination of chloramphenicol in black tiger shrimp.


Parallel Dual Column GC/MS with the AutoSpec Ultima™ NT
Library Number  720000768EN


Innovative Sample Preparation Technology Enabling High Sensitive MALDI MS Analysis
Library Number  720000769EN
This work presents a simple and robust sample preparation technology for MALDI-MS analysis by using a novel MALDI target plate, the Waters® Micromass® MassPREP PROtarget Plate. The PROtarget Plate is a uniquely-designed MALDI target plate that enables sample preparations directly on the target. A large volume (up to 10 µL) of diluted sample is placed on the target plate and dries down with focusing to a confined region coated by a membrane having peptide binding property. The region is then subsequently washed to remove contaminants that are contained in sample and may interfere with MALDI analysis, whereas analytes are selectively adsorbed onto the membrane and enriched.


A High Throughput LC/MS/MS Method for Screening Glutathione Conjugations using Exact Mass Neutral Loss
Library Number  720000770EN
Over the years, reactive metabolites are believed to have played an important role in the safety profile of pharmaceuticals. Chemically reactive metabolites of a drug can bind to proteins or DNA which is postulated to result in various direct and idiosynchratic toxicities. Therefore, this represents a key target for early screening to help prevent compound failure at a later stage. In order to address this issue, an assay has been developed to detect the formation of reactive metabolites by using LC/MS/MS with exact mass measurement to search for metabolites conjugated with glutathione from in-vitro incubations. Until recently, this work has been carried out with triple quadrupole technology using nominal mass. The advantage of the hybrid quadrupole time of flight mass spectrometer is the selectivity and sensitivity that can be achieved with it. In this presentation, we will present data to substantiate this approach and also how exact mass measurement can help to identify and postulate putative metabolites.The test substrates used herein were acetaminophen, troglitazone and raloxifene.


A Metabonomic Nephrotoxicity Study Utilizing LC/MS
Library Number  720000771EN
Metabonomics involves the study of time-related metabolic profile changes that can be the result of exposure to a toxin or drug, to environmental effects or the onset of disease. These studies are concerned with the complement of endogenous compounds rather than with xenobiotics. The primary goal is to identify and quantitate small molecules in biological systems that are affected as the direct result of an external stimulus. Knowledge of these compounds, or biomarkers, can then be used for diagnosis, screening, or to direct further research. The metabonomics approach is now being widely investigated by large pharmaceutical companies in the area of drug discovery and development where an early indication of toxicity is of paramount importance in preventing the late attrition of a potential drug candidate. 1H NMR has been the primary method of choice for analysis of changes to the profiles of complex biofluids, such as urine, as a result of toxic lesions induced by xenobiotics. We have investigated the use of exact mass LC/MS for the determination of potential biomarkers of nephrotoxicity. The gentamicin complex used in this study is an aminoglycoside antibiotic complex and a nephrotoxin.


A Novel MS-Based Metabonomic Approach to the Determination of Biomarkers of Nephrotoxicities
Library Number  720000772EN
The aim of this study was to determine whether LC/MS could be a viable alternative, or complementary to NMR spectroscopy for toxicology studies in drug discovery and development. -Analysis of a large batch of samples from a toxicology study -An integrated system consisting of a Waters® Micromass® Q-Tof micro + LockSpray + Waters Alliance® HT + MarkerLynx Application Manager -Multivariate statistical analysis for identification of the potential biomarkers of toxicity within a simple Applications Manager -The results show complementary information to 1H NMR studies


A Novel Method for HTS Screening for Phase II Conjugations for In Vivo Samples with an Orthogonal Quadrupole Time-of-Flight Mass Spectrometer Using Neutral Loss with Exact Mass
Library Number  720000773EN
During the drug discovery stages, screening and identification of in-vitro metabolites plays an important role, but remains very challenging due to the different complexity of structures being analyzed. LC/MS/MS is now a well-established technique and it plays a vital role in this early phase of Drug Discovery. With new advances in MS technology, and especially Q-Tof technology and its exact mass capabilities, good accurate data will be ensured, which is very important for metabolite identification. By the use of exact mass data, and determination of metabolite structures it will allow medicinal chemists to make the necessary ''structural tuning'' to achieve the desired compound activity. Moreover, as the demand to screen a large number of compounds in Drug Discovery increases, it is imperative to have information about Phase I and II reactions in one single experiment. In turn, this will facilitate compound selection for the next stage of drug development. Moreover, it will also provide a better predictive platform when the compound goes in-vivo. Incubation levels are also important since we want to have a reasonable concentration which may represent the levels seen in vivo. For this work we have developed a new approach to the detection of Phase II conjugations in which we can monitor Phase II conjugations such as glucuronides and so forth from a single LC run. In this paper, we will show the analytical strategy utilized to detect putative Phase II reactions based on the exact neutral loss data from a bile sample containing Midazolam and Fluanisone.


Rapid, Selective Screening of Urine Samples for Glucuronides by LC/MS/MS
Library Number  720000774EN
The traditional study of in vivo drug metabolism in plasma or urine samples is often complicated by the presence of many endogenous compounds. Several mass spectrometric techniques are often applied in drug metabolism studies. Conjugation reactions, particularly glucuronidation, can be studied using either the neutral loss or precursor ion experiment, however the experiments are not usually done at the same time. Using a hybrid quadrupole/time-of-flight instrument, a new method of performing the neutral loss and precursor ion scan experiments simultaneously hav been devised. Using this novel approach, which is more sensitive and selective than the corresponding triple quadrupole experiments, several Phase 1 and Phase 2 metabolites of diphenhydramine were identified from a human urine sample collected 4 hours after drug administration.


MALDI-TOF-MS as a Rapid and Specific Method for the Identification of Bacillus Pathogens Implicated in Biodefense
Library Number  720000775EN
The genus Bacillus, commonly referred to as the aerobic spore-bearing bacilli comprise several species that are poorly circumscribed and consequently present considerable difficulties for accurate identification (1-4). Some such as B. cereus are important foodborne pathogens while several species including B.alvei, B. megaterium, B. coagulans, B. laterosporus, B. subtilis, B. sphaericus, B. circulans, B. brevis, B. licheniformis, B. macerans, B. pumilus and B. thuringiensis are emerging as important human pathogens. At present, B. anthracis, the causative agent of anthrax, has been the focus of much attention as a potential agent for bioterrorism. Current methods of identifying species include biochemical tests, serology, long-chain cellular fatty acid analysis and more recently DNA sequence-based methods. However, because of the high degree of sequence homology between some species, a polyphasic approach which includes other rapid methods are being actively pursued. The aim of the present study is to investigate the potential of Matrix Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) as a rapid and specific method, Bacterial Mass Fingerprinting (Figures 1and 2), for the identification of Bacillus species. Once this is established, the standard operating procedures devised from this study will be used to investigate the potential of this technique for the rapid delineation of B. anthracis isolates.


ESCi Multi-Mode Ionization Source Magnet
Library Number  720000776EN


Alliance 2695 Separations Module: Optimization and Performance with 2.1 mm I.D. Intelligent Speed (IS) Columns
Library Number  720000779EN
The Alliance 2695 Separations Module delivers excellent retention time and peak area reproducibility when used with 2.1 mm i.d. IS columns.


Alliance High Throughput HPLC Systems
Library Number  720000781EN
Waters offers the Alliance High Throughput (HT) HPLC System to help laboratories meet the demand of 24 x 7 operation. Built around the 2795 Separations Module, Alliance HT Systems optimize automated sample and solvent management to shave valuable seconds from each step of the chromatography process. The system is designed specifically to improve the productivity of labs that require the selectivity and sensitivity of LC/MS to produce quality data.


2996 PHOTODIODE ARRAY AND 2487 DUAL WAVELENGTH ABSORBANCE DETECTORS: DETECTOR FLOW CELL CHOICES FOR USE WITH 2.1 mm I.D. INTELLIGENT SPEED (IS™) COLUMNS
Library Number  720000784EN
Extra-column band broadening effects are generally more important when running narrow bore chromatography than in analytical scale separations. When using Waters® Intelligent Speed (IS™) narrow bore columns, these effects are of particular importance due to the extremely narrow peaks that are generated. Waters 2996 Photodiode Array and 2487 Dual Wavelength Absorbance detectors both have optional microbore flow cells which are designed for narrow bore chromatography.


BioSuite Systems for Biopharmaceutical Characterization
Library Number  720000787EN
Biopharmaceuticals, a class of therapeutics derived from biological processes, are prescribed for a wide variety of diseases such as arthritis, breast cancer, diabetes, anemia and multiple sclerosis. Waters developed the BioSuite family of systems specifically to meet the needs of biopharmaceutical characterization scientists involved with determining protein identity, purity, potency and stability. These systems combine the power, accuracy and resolution of Micromass MS Technologies’ mass spectrometers with Waters’ reliable HPLCs, reproducible column chemistries and world renowned support services. Easy to learn and use, MassLynx 4.0 software provides system control and data management to give you complete confidence in your results.


Compliant-Ready Solutions
Library Number  720000789EN
Compliance is something that cannot be bought. However, it can be achieved through the use of compliant-ready solutions together with owner-managed SOP''s.


Temperature Control System brochure
Library Number  720000790EN
The Waters programmable Temperature Control System maintains liquid chromatography columns at consistent temperatures -- from a few degrees above ambient to 150 C.


Waters System Solutions: Purification
Library Number  720000791EN
Whether you run a few or a few hundred samples a day, Waters offers a range of complete, scalable systems that meet your isolation and purification requirements. This brochure outlines the systems, softwares and chemistries that can be used by labs doing purification, including the Waters AutoPurification System featuring the 3100 Mass Detector.


A Method for the Rapid and Sensitive Determination of Ochratoxin A in Red Wine
Library Number  720000792EN


Atlantis Columns [Chinese]
Library Number  720000793CH


Atlantis ® Säulen
Library Number  720000793DE


Atlantis ® Columns
Library Number  720000793EN


Columnas Atlantis ®
Library Number  720000793ES


Colonnes Atlantis ®
Library Number  720000793FR


Atlantis Columns [Japanese]
Library Number  720000793JA


ConnectionsAQT Whitepaper: Empower Software, Alliance Systems, SAT/IN Modules
Library Number  720000796EN
The ConnectionsAQT white paper outlines the procedure to use ConnectionsAQT for Alliance Systems, Empower Software and SAT/IN Modules. Step-by-step instructions are accompanied by photos that help explain the procedure.


Analysis of Total Homocysteine in Plasma Using a Quattro micro Tandem Mass Spectrometer
Library Number  720000797EN
Total homocysteine is currently regarded as a risk factor for cardiovascular disease. This increased interest has lead to a multitude of studies requiring the determination of total homocysteine in conjunction with other factors. This method has been shown to be rapid, precise and accurate and the simplicity of the assay makes it ideal for both non-specialized staff and routine high throughput.


APPLICATION OF A MALDI-TOF MASS SPECTRAL DATABASE FOR THE RAPID IDENTIFICATION OF MICROBES: A DEGREE OF CERTAINTY
Library Number  720000802EN
A mass spectral database of over 2000 clinical, environmental and foodborne pathogens has been developed using matrix assisted linear desorption/ionization time of flight (MALDI-TOF) mass spectrometry. The organisms represented in the database are currently all from the National Collection of Type Cultures, and represent a world-renowned well-characterized collection. This study demonstrates the increased confidence associated with identification as the number of strains per species is increased.


Analysis of Aminoglycoside Antibiotics with the Waters 2465 Electrochemical Detector
Library Number  720000803EN
Aminoglycosides are antibacterial agents used in the treatment of both animals and humans against aerobic gram-negative bacteria. This application note describes the reverse phase separation of 9 aminoglycoside antibiotics detected using pulsed amperometric detection (PAD) on a Waters® 2465 electrochemical detector (ECD).


2420 Evaporative Light Scattering Detector
Library Number  720000804EN


2777 Sample Manager: Staggered Chromatography Option
Library Number  720000805EN


2777 Sample Manager: Preparative Upgrade Options
Library Number  720000806EN


A Glossary for Mass Spectrometry by Kenneth L. Busch
Library Number  720000807EN
Like any scientific discipline, mass spectrometry (MS) uses specialized terms that describe its instruments, procedures, and results. These terms are often used without definition or explanation in technical presentations that involve MS. The purpose of this glossary is to compile some of the more widely used terms that non-mass spectrometrists may encounter, and for which a simple definition would be helpful. The definitions are necessarily brief, but should be sufficient to provide basic understanding.


Mass Analyzers for LC-MS by Filip Lemičre
Library Number  720000808EN
The major technical challenge in liquid chromatography–mass spectrometry (LCMS) is interfacing the chromatographic and spectrometric components. This observation implies that any mass spectrometer potentially can be coupled to an LC or other separation system. Understanding the different working principles and technical properties of different MS instruments gives an insight into the technical possibilities and limitations that must be acknowledged when coupling MS with LC. The characteristics of different MS instruments also determine their applications in the various LC-MS research fields, and the requirements imposed by the analytical question determine the type of MS to couple to the LC system. Ultimately, the only limit to the coupling of LC to MS is the imagination of the analyst setting up the hyphenated experiment.


Waters System Solutions for High Sensitivity LC/MS/MS with Waters CapLC XE/Q-Tof Systems: Delivering Superior Performance
Library Number  720000809EN
The Waters CapLC® XE System is innovative technology that provides an unprecedented level of integration for capillary- and nano-scale LC and MS. The CapLC XE/Q-Tof System is the only single-vendor solution for exact mass, high sensitivity LC/MS/MS analyses. Since first shipment of the CapLC System in 1999, high sensitivity analyses have demanded high retention time reproducibility and increased system uptime. To continue to meet these demands, Waters has implemented new component technologies designed to increase system reliability and overall robustness of the CapLC XE/Q-Tof System. These enhancements include newly re-designed pump check valves, new operating firmware for the CapLC XE Pump, new eluent filters, an in-factory application-specific test and on-site system-level integration tests to ensure that the CapLC XE System with Q-Tof mass spectrometer performs as expected in your laboratory.


LCT Premier - Routine Automated Exact Mass Measurement
Library Number  720000810EN

As with every analytical tool, the more accurate your measurement the more confident you can be with your results. For example, when carrying out a metabolism investigation following an in vivo experiment are you sure that a peak detected at m/z 342.1 is an actual metabolite or a matrix-related component or even a solvent contaminant? Mass measuring the peak of interest to 4 decimal places will give you that confidence.

By reducing the error on a mass measurement, the possible elemental formulae that can match a particular measurement significantly reduce, therefore providing better specificity. Such mass measurement accuracy is not routinely available with typical scanning instruments such as quadrupole or ion trap mass spectrometers. For routine and easy-to-use exact mass measurement, orthogonal acceleration time-of-flight (oa-TOF) mass spectrometry provides the solution.

Exact mass measurement on an oa-TOF can help to determine the elemental compositions of analytes, distinguish between nominally isobaric components, distinguish between analyte and matrix-related material, improve database search specificity, and increase your confidence in analyte identification.



2487 Dual Wavelength Absorbance Detector: Optimization for Intelligent Speed (IS™) Columns
Library Number  720000814EN


2777C Sample Manager specifications
Library Number  720000815EN


Waters Laboratory Informatics: capabilities brochure
Library Number  720000817EN
This brochure overviews Waters Laboratory Informatics. Our software-based solutions bridge all instruments, data sources, and legacy corporate information centers. Waters solutions capture, catalogue, and centralize all scientific content. The suite of Waters Laboratory Informatics products helps organizations share knowledge and manage intellectual property throughout the global workplace.


Waters Laboratory Informatics: interactive product guide (mini-CD)
Library Number  720000818EN

This is an interactive CD providing an overview of the Waters Laboratory Informatics suite. The presentation includes information about the four core software products making up our suite: the eLabNotebook, NuGenesis SDMS (Scientific Data Management System), Empower, and MassLynx.

To request the mini-CD, please click the Request a mini-CD link , and then check off the Hard Copy box .



Ultra Performance Liquid Chromatography (UPLC): New Boundaries for the Chromatography Laboratory White Paper
Library Number  720000819EN
At a time when many scientists have reached separation barriers and are pushing the limits of conventional HPLC, Ultra Performance Liquid Chromatography presents the possibility to extend and expand the utility of this widely used separation science. When properly commercialized, the UPLC technique will gain wide acceptance in the laboratory due to its ability to provide more information per unit of work as it fulfills the promise of increased speed, resolution and sensitivity predicted for liquid chromatography.


ACQUITY UPLC System brochure (Chinese)
Library Number  720000820CH
Introducing the Waters ACQUITY Ultra Performance LC™ (UPLC™) System, the integrated system solution for LC, LC/MS and LC/MS/MS applications that''s ushering in a whole new era of speed, sensitivity and resolution.

ACQUITY UPLC™ Systems are holistically designed to significantly reduce run times by up to ten times. By working synergistically with ACQUITY Ultra Performance LC Column chemistries, this UPLC technique optimizes ultra-low dwell volumes while taking advantage of the low-dispersion, high-speed detectors necessary for successful analysis.

When all these technologies combine, it accelerates the levels of sample throughput, sensitivity and resolution. This gives you the speed you require to be productive and the sensitivity and resolution you need to be confident in today''s high throughput laboratories.


ACQUITY UPLC System brochure (German)
Library Number  720000820DE
Introducing the Waters ACQUITY Ultra Performance LC™ (UPLC™) System, the integrated system solution for LC, LC/MS and LC/MS/MS applications that''s ushering in a whole new era of speed, sensitivity and resolution.

ACQUITY UPLC™ Systems are holistically designed to significantly reduce run times by up to ten times. By working synergistically with ACQUITY Ultra Performance LC™ Column chemistries, this UPLC technique optimizes ultra-low dwell volumes while taking advantage of the low-dispersion, high-speed detectors necessary for successful analysis.

When all these technologies combine, it accelerates the levels of sample throughput, sensitivity and resolution. This gives you the speed you require to be productive and the sensitivity and resolution you need to be confident in today''s high throughput laboratories.


ACQUITY UPLC System brochure (Spanish)
Library Number  720000820ES
Introducing the Waters ACQUITY Ultra Performance LC™ (UPLC™) System, the integrated system solution for LC, LC/MS and LC/MS/MS applications that''s ushering in a whole new era of speed, sensitivity and resolution.

ACQUITY UPLC™ Systems are holistically designed to significantly reduce run times by up to ten times. By working synergistically with ACQUITY Ultra Performance LC column chemistries, this UPLC technique optimizes ultra-low dwell volumes while taking advantage of the low-dispersion, high-speed detectors necessary for successful analysis.

When all these technologies combine, it accelerates the levels of sample throughput, sensitivity and resolution. This gives you the speed you require to be productive and the sensitivity and resolution you need to be confident in today''s high throughput laboratories.


ACQUITY UPLC System brochure (French)
Library Number  720000820FR
Introducing the Waters ACQUITY Ultra Performance LC™ (UPLC™) System, the integrated system solution for LC, LC/MS and LC/MS/MS applications that''s ushering in a whole new era of speed, sensitivity and resolution.

ACQUITY UPLC™ Systems are holistically designed to significantly reduce run times by up to ten times. By working synergistically with ACQUITY Ultra Performance LC™ Column chemistries, this UPLC technique optimizes ultra-low dwell volumes while taking advantage of the low-dispersion, high-speed detectors necessary for successful analysis.

When all these technologies combine, it accelerates the levels of sample throughput, sensitivity and resolution. This gives you the speed you require to be productive and the sensitivity and resolution you need to be confident in today''s high throughput laboratories.


ACQUITY UPLC System brochure (Italian)
Library Number  720000820IT
Introducing the Waters ACQUITY Ultra Performance LC™ (UPLC™) System, the integrated system solution for LC, LC/MS and LC/MS/MS applications that''s ushering in a whole new era of speed, sensitivity and resolution.

ACQUITY UPLC™ Systems are holistically designed to significantly reduce run times by up to ten times. By working synergistically with ACQUITY Ultra Performance LC™ Column chemistries, this UPLC technique optimizes ultra-low dwell volumes while taking advantage of the low-dispersion, high-speed detectors necessary for successful analysis.

When all these technologies combine, it accelerates the levels of sample throughput, sensitivity and resolution. This gives you the speed you require to be productive and the sensitivity and resolution you need to be confident in today''s high throughput laboratories.


ACQUITY UPLC System brochure (Japanese)
Library Number  720000820JA
Introducing the Waters ACQUITY Ultra Performance LC™ (UPLC™) System, the integrated system solution for LC, LC/MS and LC/MS/MS applications that''s ushering in a whole new era of speed, sensitivity and resolution.

ACQUITY UPLC™ Systems are holistically designed to significantly reduce run times by up to ten times. By working synergistically with ACQUITY Ultra Performance LC™ Column chemistries, this UPLC technique optimizes ultra-low dwell volumes while taking advantage of the low-dispersion, high-speed detectors necessary for successful analysis.

When all these technologies combine, it accelerates the levels of sample throughput, sensitivity and resolution. This gives you the speed you require to be productive and the sensitivity and resolution you need to be confident in today''s high throughput laboratories.


Early Candidate Profiling (ECP) System, with ProfileLynx Application Manager
Library Number  720000823EN
Waters Early Candidate Profiling (ECP) Systems provide an automated solution for determining which compounds have the physicochemical potential to become successful therapeutics. These system solutions combine the strengths of Waters instruments, chemistries, software and customer support to assist discovery labs in characterizing compounds faster, easier, and more cost-effectively.


Evaluation of the Quattro Premier for the analysis of verapamil in protein-precipitated plasma
Library Number  720000824EN
The Quattro Premier™ tandem quadrupole mass spectrometer has a newly developed ZSpray™ interface designed to meet the demands of high throughput analyses from biological matrices in the pharmaceutical industry. In this environment robustness and sensitivity are the driving forces for successful bioanalysis. The following study has been developed to evaluate the source robustness by injecting samples of verapamil spiked into human plasma. The spiked plasma was protein-precipitated and the supernatant injected directly into the source. The study ran over a 24-hour period in positive ion electrospray ionization mode (ESI+ve).


Quantification of 17-Hydroxyprogesterone in Protein-Precipitated Plasma using the Quattro Premier
Library Number  720000825EN
Atmospheric Pressure Chemical Ionization (APCI) is often cited as the technique of choice for improved linearity in quantitative LC/MS/MS. In this technical note we show the newly developed Waters Quattro Premier tandem quadrupole mass spectrometer in the analysis of 17-hydroxyprogesterone in protein-precipitated plasma. The calibration curve was plotted over five orders linear dynamic range of concentration, indicating excellent dynamic range that will be beneficial in dose ranging studies.


EVALUATION OF THE QUATTRO PREMIER™ FOR THE QUANTIFICATION OF SULFADIMETHOXINE IN HANKS BALANCED SALT SOLUTION
Library Number  720000826EN
The Waters® Micromass® Quattro Premier™ tandem quadrupole mass spectrometer incorporates new developments to the ZSpray™ dual orthogonal API interface designed to meet the demands of the pharmaceutical industry. In this environment robustness and sensitivity are the driving forces for successful bioanalysis. The following study has been developed to evaluate source robustness by injecting samples of sulfadimethoxine spiked into Hanks Balanced Salt Solution (HBSS) directly into the source without any dilution. The study ran over a 24-hour period in negative ion atmospheric pressure chemical ionization mode (APCI-ve).


AMDS Method Transfer: Addressing Temperature Selectivity Issues with Transferring Methods between HPLC Manufacturers
Library Number  720000827EN
HPLC vendor designs can dramatically impact how a method performs during the transfer process. Transferring methods with column heater design differences poses a challenge. Waters Automated Method Development System (AMDS) can be a useful tool to assist in method transfers between instruments of different designs. AMDS not only reduces the effort involved—it can help identify and troubleshoot any problems.


Ultra Trace Analysis Of Dioxins And Furans In Human Adipose Tissue Using SFE-LC Extraction/Cleanup and the Waters AutoSpec Ultima NT
Library Number  720000829EN


626 LC System specifications
Library Number  720000830EN


Peptide Mapping Using BioSuite PA Columns: High Peak Capacity for Separation of Complex Peptide Mixtures
Library Number  720000833EN
Complex peptide samples generated by protein digestion may contain tens to hundreds of components. Separations are performed in RP-HPLC mode under gradient conditions. Given the complexity of the digest, highly efficient columns are required for successful separation. The separation efficiency of the columns when using gradient elution is described by column peak capacity (P), rather than by theoretical plates. Peak capacity is defined as the number of peaks that can be theoretically separated within a gradient time. State-of--the-art RP-HPLC columns have peak capacities of 100-300, depending on their length and particle size of sorbent. Using longer columns and/or long gradients improves the P, however, at the expense of separation time. BioSuite™ PA-A and PA-B columns packed with 3 and 3.5 µm sorbent, respectively, offer the high peak capacity required for complex sample separations. Other column design features including base sorbent, ligand binding, encapping, and column hardware are also crucial for peptide separation performance. Both BioSuite™ PA-A and PA-B columns are ideally suitable for peptide mapping applications.


1500 Series Solvent Delivery Systems
Library Number  720000835EN
Waters 1500 Series HPLC pumps have been designed to meet all of your flow range needs, from low flow to semi-preparative. Learn more about the full line of 1500 Series solvent delivery systems.


Determination of Pesticide Residues in Complex Matrices Using the Waters Micromass Quattro Premier: A Method Combining Extreme Sensitivity and Unmatched Robustness
Library Number  720000839EN
The Food and Veterinary Office of the European Commission has published a report (2001 pesticide residues monitoring programme1) compiling EU wide analyses of pesticide residues in 46000 samples of fruits, vegetables and cereals. Detectable residues were found in 37% of the samples, 3.6% of the sample contained residue levels above the EC MRLs. The percentage of samples with no detectable residues is shown to have slightly decreased compared to previous years, whereas the percentage of samples with residues at or below the MRL has increased. These results do not reflect a real change in the residue situation, but rather an improvement in the analytical instrumentation used in modern laboratories. Techniques are becoming more and more efficient, allowing the detection and quantification of lower amounts and a higher number of various pesticides.


An Enhanced LC/MS/MS Method for the Determination of 81 Pesticide Residues in Fruit and Vegetables Using the Quattro Premier Mass Spectrometer
Library Number  720000840EN
Worldwide, there are over 800 pesticides currently in use to control undesirable weeds, insects, rodents and fungi. The legal enforcement of regulations governing pesticide use requires the regular monitoring of agricultural produce. Food produce used for human consumption must contain less than the statutory Maximum Residue Limit (MRL) of any given pesticide. Given the large number of pesticide residues that may be found in foodstuffs, it is advantageous to determine as many as possible during a single analysis.


Waters Industry Solutions: Pharmaceuticals
Library Number  720000841EN

This brochure describes Waters'' capabilities for the pharmaceutical industry.

Waters offers core strengths in sample preparation, liquid chromatography (UPLC and HPLC), mass spectrometry, and laboratory informatics. We partner with pharmaceutical companies around the world to provide forward-looking technologies and services necessary to support pharmaceutical research and development.

Waters provides complete solutions across the entire pharmaceutical discovery, development and manufacturing process, including:

  • Target discovery and identification
  • Lead discovery
  • Lead optimization
  • Bioanalysis
  • Safety assessment
  • Chemical and pharmaceutical development
  • Quality assurance and control (QA/QC)


NuGenesis SDMS 7.0 Software
Library Number  720000842EN

Waters NuGenesis SDMS (Scientific Data Managment System) provides laboratories with an effective foundation for scientific information management by making data easier to access, facilitating compliance with regulatory requirements, and aiding in the administration of intellectual property throught its lifecycle.

With the NuGenesis SDMS platform, disparate data generated by instruments, scientists, and outside sources is automatically imported into a centralized data warehouse. This information can easily be searched, communicated, and shared among scientists and collaborative team members -- delivering measurable gains in time-to-market and employee efficiency while reducing cost and risk.

By integrating all scientific information, NuGenesis SDMS serves as the nerve center of the Waters Laboratory Informatics suite of products.



Enhanced Identification of Trace-Level Peptides from Complex Protein Digests Using the Ionalytics Selectra in LC/MS Experiments
Library Number  720000843EN
The Ionalytics™ Selectra™ is an ion-filtering device providing additional, orthogonal separation prior to LC/MS and LC/MS/MS experiments, and is fully integrated with a range of Waters® Micromass® mass spectrometers. The Ionalytics Selectra uses FAIMS (high-field asymmetric waveform ion mobility spectrometry) technology to separate gas-phase ions based on changes in mobility that occur as a function of their electric field strength. As a result, the use of FAIMS with Electrospray MS and MS/MS analyses on Waters Micromass MS systems provides an easy route to enhance the detection and characterization of proteins, peptides, various other biomolecules and small molecules. Protein identification using nano-LC/MS/MS provides reliable sequencing information for low femtomole levels of in-gel digests. However, this task is more challenging for sub-femtomole peptide levels as precursor detection is often compromised by the presence of chemical noise associated with the ionization of the mobile phase constituents and column bleed. This application note describes how researchers at Caprion Pharmaceuticals (Montreal, Canada) used the Ionalytics Selectra integrated with a Waters Micromass Q-Tof™ mass spectrometer to help identify these trace level peptides.


Linked Scanning for the Autospec Ultima NT Mass Spectrometer
Library Number  720000844EN


The Determination Of Acrylamide Using the Quattro Premier LC/MS/MS System
Library Number  720000846EN


Determination of Nitrofuran Veterinary Drug Residues Using Waters Micromass Quattro Premier: Tandem Mass Spectrometer
Library Number  720000847EN


Sample Prep Solutions Brochure - Chinese Translation
Library Number  720000848CT


Sample Prep Solutions Brochure - German Translation
Library Number  720000848DE


Sample Prep Solutions Brochure
Library Number  720000848EN


Sample Prep Solutions Brochure - Spanish Translation
Library Number  720000848ES


Sample Prep Solutions Brochure - French Translation
Library Number  720000848FR


Sample Prep Solutions Brochure - Japanese Translation
Library Number  720000848JA


High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) for Waters® Micromass® Mass Spectrometers
Library Number  720000850EN
The Ionalytics Selectra™ provides reduced background and enhanced selectivity on your mass spectrometer. The Ionalytics Selectra offers re s e a rchers within the proteomics and drug discovery fields a unique tool to enhance their analyses. Using a dynamic ion-filtering mechanism, the Ionalytics Selectra improves the performance of mass spectrometers in both qualitative and quantitative applications by providing an additional dimension of ion separation. The outcome is clearer analytical results provided by reduced chemical background, separation of isobaric interferences, and improved detection limits in LC/MS applications. Operating at ambient conditions, the Ionalytics Selectra is easily installed between an existing atmospheric pressure ionization source and mass spectrometer with minimal disruption to instrument configurations. Its unique ion-focusing mechanism maintains analyte intensity while its post-source placement reduces chemical background.


Exact Mass and High Resolution Precursor Ion Selection on a Q-Tof Ultima MALDI for de novo Peptide Sequencing
Library Number  720000852EN
The aim of the analysis was the identification by MALDI MS/MS of two unidentified peptides, that differ in mass by only 3 Daltons in the MALDI MS experiment.
• The experiment involved MS/MS analysis of tryptically digested peptides on a MALDI quadrupole orthogonal acceleration time-of-flight mass spectrometer
• High resolution precursor ion selection was achieved using a quadrupole mass filter, allowing MS/MS to be performed on peptides of similar mass
• Confident de novo sequencing of the peptides was performed using Waters MassSeq algorithm using exact mass measured MS/MS data


A Study of the Analysis of Polybrominated Diphenyl Ether Flame Retardants by GC/MS/MS
Library Number  720000855EN
Polybrominated diphenyl ether (BDE) flame retardants having been of increasing concern to environmental analysts in recent years, making front page news1. Current analytical techniques for BDE analysis generally involve the use of HRGC-HRMS, a costly technique requiring highly trained operators. Methods have recently been published using single quadrupole GC/MS2,3, or GC/MS/MS (iontrap)4. The purpose of this study was to investigate the suitability of a GC triple-quadrupole instrument for the analysis of BDEs, monitoring compound specific fragmentation patterns with the use of multiple reaction monitoring (MRM) acquisitions.


AssetCARE Asset Managment Service
Library Number  720000856EN
Our AssetCARE Asset Management Service maintains a comprehensive inventory of your Waters laboratory instrumentation and provides you with a detailed service and maintenance history for each instrument. We will locate your Waters instruments, track them, ensure their timely scheduled service, and analyze your maintenance spending to assist you in lowering your overall cost of ownership. Just log on to a personalized Web portal for instant, accurate information.


Sirocco Interactive Product Guide
Library Number  720000858EN


Waters Certified Vials
Library Number  720000859EN
Waters understands the importance of quality and reliability and is involved throughout the entire process – sample preparation, instrumentation, chemistry, detection and data collection. We realize that your lab is under pressure to produce. We are the only company in the industry to offer HPLC and GC Certified Vials.



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